The purpose of the Royal North Shore Hospital Department of Dermatology Translational Medicine Laboratory is to discover and refine better and accessible therapies through clinically relevant laboratory studies. We aim to be the premier laboratory for dermatology translational studies and for dermatological clinician-scientists to work globally.
We hope that within our lifetimes we will see targeted therapies for all dermatological conditions. We are well placed to achieve this given our talented team, our access to state of the art equipment within the Kolling Institute and the University of Sydney, and our emphasis on clinical observation.
Current Translational Projects:
- Cellular and molecular pathophysiology of chronic vulvovaginal candidiasis (CVVC).
The lifetime risk of a woman developing CVVC is as high as 5%. CVVC is continuous and unremitting, and its causes are poorly understood. With our clinical observation that post-menopausal women who have commenced hormone replacement therapy (HRT) are significantly more likely to develop CVVC (49% vs 1%), we are investigating the intrinsic cellular, molecular, and proteomic changes that occur during HRT, to understand why these women are at a higher risk of developing chronic vulvovaginal candidiasis
- Targeting synaptic gating with piloerection and frisson to ameliorate pruritus.
Pruritus (itch) is the flagship symptom of many dermatological, oncological, and chronic systemic conditions, however unlike pain, there are currently no targeted therapies for pruritus. There are both central and peripheral, inflammatory and neurogenic, mediators of pruritus, and we have observed clinically that patients who experience frisson-associated goosebumps no longer have itch symptoms. We aim to determine how to pharmacologically target piloerection and frisson to treat pruritus.
To enquire about any of our existing or upcoming translational studies, please contact our Research Fellow: email@example.com