A3BC MSK Biobank

Rheumatology

The Florance and Cope Professorial Department of Rheumatology brings together scientific researchers and medical clinicians with a common interest in improving outcomes for those with musculoskeletal conditions.

We are currently conducting research into the causes, impact and treatment of a wide range of disorders in addition to raising awareness of the burden of musculoskeletal conditions.

Our aim is to advance the understanding of the musculoskeletal system. The main focus of our research includes clinical and translational research in inflammatory arthritis, osteoarthritislow back pain and other rheumatic diseases. While these areas are a focus, our clinicians and researchers are also investigating osteonecrosis, systemic lupus erythematosus, rheumatoid arthritis and psoriatic arthritis.

Our researchers are members of national and international advisory committees that raise awareness and promote care and research on musculoskeletal conditions. We are the Home Office for the Global Alliance for Musculoskeletal Conditions.

We are the national lead site for A3BC – the Australian Arthritis and Autoimmune diseases Biobank Collaborative, and we encourage the involvement of patient research partners in all our projects.

We aim to make precision medicine – giving the targeted right treatment to the right patient at the right time – a reality. Through all of our work we are building a national resource to work towards a cure for musculoskeletal conditions

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Professor Lyn March AM

Professor Lyn March AM

Project Lead and Coordinating Principal Investigator
Australian Arthritis and Autoimmune Biobank Collaborative (Uni Syd)
Liggins Professor of Rheumatology & Musculoskeletal Epidemiology
Institute of Bone and Joint Research, Kolling Institute
Head of Department
Department of Rheumatology, Royal North Shore Hospital

Lyn is the Head of Rheumatology at Sydney’s Royal North Shore Hospital and Liggins Professor of Rheumatology and Musculoskeletal Epidemiology at Sydney University.

Lyn graduated from medicine with first class honours from the University of Sydney, then went on to gain a PhD from Sydney and a MSc from the London School of Hygiene and Tropical Medicine. She has been an active clinician and researcher for more than 25 years. She was made a Member of the Order of Australia for her significant services in the areas of rheumatology and clinical epidemiology as an academic, researcher and clinician. She led the international expert group that generated the latest global burden of musculoskeletal disease data. Lyn is an executive member of OMERACT the international group standardising patient reported outcome measures in rheumatology, on the Executive Committee for the Global Alliance for MSK Health, Co-lead of their Surveillance Task Force and member of their WHO working party. Lyn advocates to raise the profile of musculoskeletal conditions and to improve evidence-based patient care through policy development and translational and discovery research. She co-led the NSW Health Agency for Clinical Innovation’s MSK Network during the development of the MSK Models of Care now part of Leading Better Value Care. Her latest challenge is the establishment of the A3BC – a national collaboration linking the patient outcomes registry ARAD with a new biospecimens network to deliver precision medicine to the individual patient and build a national research resource working to find a cure for arthritis and autoimmune rheumatic conditions.

Associate Professor Sean O'Neill

Associate Professor Sean O’Neill

Associate Professor Rheumatology, Northern Clinical School

Dr Rodger Laurent

Clinical Senior Lecturer

Dr Premarani Sinnathurai

Clinical Lecturer. Northern Clinical School

Dr Shirley Yu

Clinical Lecturer, Northern Clinical School, University of Sydney

Dr Marita Cross

Dr Marita Cross

Postdoctoral Research Associate, Northern Clinical School

Lyndall Henderson

Medical Research Officer

Tom Lynch

National A3BC Project Officer

Jie Yi

Clinical Trials Coordinator

Tahnee McEwan

Research Fellow

The aim of the rheumatology department is to advance the understanding of the musculoskeletal system. The main focus of our research includes clinical and translational research in osteoarthritis, low back pain and other rheumatic diseases.

Using a combination of clinical, data science and laboratory research methods this PhD project aims to investigate predictors and predictive models of inflammatory arthritis using samples and data from a national biobank-registry project, the Australian Arthritis and Autoimmune Biobank Collaborative (A3BC) and Australian Rheumatology Association Database (ARAD). The primary hypothesis is that inflammatory arthritis outcomes can be predicted and optimised by integrating diverse predictor variables across clinical, biological, self-reported, biometric and administrative health data domains to inform critical management decisions at key timepoints in the disease course. The ultimate goals of this field are improved population medicine policy and practice in the form of new, improved and more targeted treatments, better preventative and management strategies and, ideally, progress towards complete cures for these diseases. The expected research contribution is a thesis containing a series of publications around the common themes of personalised / precision medicine in inflammatory arthritis, predictive modelling, and the role of biobank-registries in facilitating this type of research.

https://kollinginstitute.org.au/osteoarthritis-research

https://kollinginstitute.org.au/back-pain-research

https://kollinginstitute.org.au/sutton-arthritis-research-laboratory

  • The causes, impact and treatment of a wide range of musculoskeletal/ rheumatological disorders.
  • Key research areas: inflammatory arthritis (rheumatoid arthritis, psoriatic arthritis, etc), systemic lupus erythematosus, osteoarthritis, osteoporosis, low back pain.
  • Development and implementation of evidence-based clinical guidelines.
  • Global Burden of Diseases Study (Musculoskeletal disorders).
  • The A3BC Biobank (https://a3bc.org.au/)
  • ARAD (https://www.arad.org.au/Public/Home.aspx)
  • Baricitinib therapy for rheumatoid arthritis: an observational study.

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