Bill Walsh Translational Cancer Research Laboratory

Brain Cancer:

1. Teaching an Old Drug New Tricks: Can we repurpose an old drug as a new brain cancer treatment?
2. The immuno-coagulome: an untapped pathway for new therapeutics in glioma
3. Investigating how glioblastoma tumours change over time to become resistant to treatment
4. Unravelling the tumour micro-environment to combat brain cancer
5. Laying the foundations for improved treatments for IDH-mutated glioma
6. The interaction between coagulation, angiogenesis and inflammatory pathways in glioblastoma
7. MHF Brain Cancer PACT: Mark Hughes Foundation Collaborative Brain Cancer Pre-clinical pipeline for Advancing Cancer Therapeutics
8. Development of non-invasive monitoring for brain tumour recurrence and treatment resistance
9. A new class of theranostics for malignant brain cancer
10. Radiosensitisation of high-grade gliomas by modulating glucose metabolism
11. New Horizons: Therapeutic applications for medicinal cannabis in the treatment of brain cancer

Colorectal Cancer:

1. The role ofIinflammation in colorectal cancer
2. Identifying prognostic protein markers in colorectal cancer tumour
3. Exploring a new nanotechnology strategy for the neo-adjuvant treatment of colorectal cancer by photodynamic therapy and ionising radiation

Lung Cancer:

1. Investigating patterns of drug resistance in ALK rearranged non-small cell lung cancer
2. Exploring methods to improve efficacy of immunotherapy in non-small cell lung cancer
3. Identification of biomarkers for non-small cell lung cancer
4. Chemotherapy resistance in non-small cell lung cancer
5. The exhaled breath condensate proteome: a promising source of biomarkers for lung cancer

Mesothelioma:

1. Improved treatment for mesothelioma: Can cannabinoids address this unmet need?

Neuroendocrine Tumours:

1. The role of dual PET scans in understanding neuroendocrine tumour behaviour
2. Analysing PET scans for neuroendocrine tumours

Ovarian Cancer:

1. Evaluation of lysyl oxidase inhibitors as a new treatment for ovarian cancer
2. Investigating the role of long non-coding RNA (ribonucleic acid) in the ovarian cancer microenvironment
3. Improving ovarian cancer treatment using nanoparticles

Pancreatic Cancer:

1. Biomarker identification for pancreatic cancer diagnosis
2. Biomarker identification for pancreatic cancer prognosis.
3. Identification of new drug targets for pancreatic cancer treatment
4. Understanding the role of tumour microenvironment in pancreatic cancer progression