Diabetes and Obesity Clinical Trials Unit

Our mission focuses on crucial moments to prevent diabetes and obesity. We aim to reduce risks like gestational diabetes, blood sugar instability, and obesity in people with and without diabetes.

By utilizing advanced tools like continuous glucose monitors and innovative medications, alongside a dedicated team of experts including doctors, scientists, dietitians, and exercise specialists, we strive to improve health outcomes. Our goal is to explore these challenges and enhance care standards, ensuring people lead healthier lives now and in the future.

To register interest in participating in our clinical trials, please email at:
NSLHD-EndocrineResearch@health.nsw.gov.au
Please provide :
First Name
Last Name
Email Id
Phone Number
Patient population for clinical trials: type 1 diabetes, type 2 diabetes, gestational diabetes, pre-existing diabetes in pregnancy, obesity.

Lead

People

Publications

Professor Sarah Glastras

Head of Department, Senior Staff Specialist, Department of Diabetes, Endocrinology and Metabolism.
Principal Research Lead, Pregnancy, Obesity and Diabetes, Kolling Institute, the University of Sydney.

Dr Matilda Longfield

Dr Matilda Longfield

Dr Natassia Rodrigo

PhD Student

Linda Wu

Research Assistant

Amanda Purcell – PhD Student

Cameron Evans

PhD Student

Purcell AR, Zhen XM, Wong J, Glastras SJ. Glucagon-like peptide-1 receptor agonist treatment reduces body weight and improves glycaemic outcomes in patients with concurrent overweight/obesity and type 1 diabetes: A systematic review and meta-analysis. Diabetes Obes Metab. 2026; 28(1): 296-305. doi:10.1111/dom.70188

Narayan, K., Auzanneau, M., Ospelt, E., Rompicherla, S., Ebekozien, O., Glastras, S., Smart, C., Bachmann, S., Welp, R., Maahs, D. and Craig, M.E., 2026. Variability in Body Mass Index during 2018–2021 for People with Type 1 Diabetes: Real World Data from the USA, Germany, and Australasia. Hormone Research in Paediatrics99(1), pp.138-146.

Punnose, J., Göbl, C.S., Glastras, S.J. and Tura, A., 2026. Recent advances in gestational diabetes: diagnosis, treatment and prevention. Frontiers in Endocrinology17, p.1773541.

Purcell AR, Rodrigo N, Longfield MSG, Glastras SJ, Tirzepatide for the treatment of adults living with concurrent type 1 diabetes and overweight or obesity (TZP-T1D): a double-blind, placebo-matched randomised controlled trial protocol, BMJ Open 2025;15:e093775. doi: 10.1136/bmjopen-2024-093775

Rickard X, Longfield MSG, Zhou J, et al. The impact of obesity on pregnancy outcomes in women with type 1 and type 2 diabetes across the NSW population: A retrospective cohort study. Diabet Med. 2025; 00:e70177. doi:10.1111/dme.70177

Randall D, Ibiebele I, Nippita T, et al, StUdy of Gestational diabetes And Risk using Electronic Data (SUGARED): a population-based cohort study—study protocol, BMJ Open 2024;14:e087248. doi: 10.1136/bmjopen-2024-087248

Weir TL, Majumder M, Glastras SJ. A systematic review of the effects of maternal obesity on neonatal outcomes in women with gestational diabetes. Obesity Reviews. 2024; 25(7):e13747. doi:10.1111/obr.13747

Weir TL, Majumder M, Glastras SJ. Assessing the independent and combined impact of obesity and gestational diabetes mellitus on adverse maternal outcomes: A systematic review and meta-analysis. Diabet Med. 2025; 00:e70172. doi:10.1111/dme.70172

Haigh C, Lau HWR, Weir T, Glastras S. The experiences of women from culturally and linguistically diverse backgrounds with gestational diabetes mellitus: A mixed methods systematic review. Endocrinol Diab Metab. 2023; 6:e0421. doi:10.1002/edm2.421

Lau, H.W.R., et al., Improving women’s experiences with gestational diabetes from culturally and linguistically diverse backgrounds in Australia: a qualitative study. Frontiers in Public Health, 2024. Volume 11 – 2023.

Purcell AR, Rodrigo N, Cao Q, Joseph O, Gill AJ, Saad S, Pollock CA, Glastras SJ. Maternal Weight Intervention in the Perinatal Period Improves Liver Health in the Offspring of Mothers with Obesity. Nutrients. 2023 Dec 28;16(1):109. doi: 10.3390/nu16010109. PMID: 38201940; PMCID: PMC10780988.

Rodrigo N, Glastras SJ. The Emerging Role of Biomarkers in the Diagnosis of Gestational Diabetes Mellitus. Journal of Clinical Medicine. 2018; 7(6):120. https://doi.org/10.3390/jcm7060120

Rodrigo N, Saad S, Pollock C, Glastras SJ. Diet Modification before or during Pregnancy on Maternal and Foetal Outcomes in Rodent Models of Maternal Obesity. Nutrients. 2022; 14(10):2154. https://doi.org/10.3390/nu14102154

Rodrigo, N., Chen, H., Pollock, C. A., & Glastras, S. J. (2022). Preconception weight loss improves fertility and maternal outcomes in obese mice. Journal of Endocrinology, 253(1), 27-38. Retrieved Jan 15, 2026, from https://doi.org/10.1530/JOE-21-0399

Rodrigo, N., Learoyd, D., & Glastras, S. J. (2021). Complexities surrounding the diagnosis and management of hypercalcaemia in pregnancy. Endocrinology, Diabetes & Metabolism Case Reports, 2021, Article 20-0163, 20-0163. Retrieved Jan 15, 2026, from https://doi.org/10.1530/EDM-20-0163

Rodrigo, N., Chen, H., Pollock, C.A. et al. Kidney outcomes are altered by preconception weight modulation in rodent mothers with obesity. Sci Rep 14, 17363 (2024). https://doi.org/10.1038/s41598-024-68234-9

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