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  • Kolling researcher recognised with prestigious international award

    Kolling researcher recognised with prestigious international award

    We would like to congratulate Professor Chris Little who has received a highly coveted award for his outstanding commitment to orthopaedic research.

    Professor Little has been elected a Fellow of International Orthopaedic Research at a key international conference in Edinburgh Scotland. The award is only presented every three years, with around 20 people across the globe receiving the accolade.

    Fellows are recognised for their leadership, service, achievement and dedication to the field of orthopaedic research.

    Chris has welcomed the recognition, while acknowledging the support he’s received.

    “I am very proud to have been made a Fellow of International Orthopaedic Research,” he said.

    “While I have received the award, it’s actually a reflection of the wonderful work that has been done by all the researchers in my group over the years.”

    “It is an honour to be nominated by one of the International Combined Orthopaedic Research Societies (ICORS) – and in my case, the US Orthopaedic Research Society.

    “ICORS member organisations are represented across the world. They have a crucial role advancing orthopaedic and musculoskeletal research by promoting basic, translational, and clinical research worldwide.

    “This is an important part of progressing valuable research across the globe and improving long-term health outcomes.”

    Chris was presented with the award by ICORS president Gun-Il Im and FIOR Chair Brian Johnstone, who thanked him for his outstanding leadership and dedication to orthopaedic and musculoskeletal research.

    Chris has a clinical and research career spanning more than three decades. He is the Director of the Raymond Purves Bone and Joint Research Lab at the Kolling Institute and a member of the Charles Perkins Centre.

    Chris is a qualified veterinarian with specialist surgery training. His research focuses on defining the biochemical and molecular mechanisms of joint pathology in osteoarthritis, as well as tendon and intervertebral disc degeneration. 

  • New robot driving innovation in joint surgery

    New robot driving innovation in joint surgery

    A $400,000 robot which may hold the key to significant improvements in hip and knee replacements is now operational at the Kolling Institute.

    Known as KOBRA or the Kolling Orthopaedic Biomechanics Robotic Arm, the new technology delivers an advanced testing facility, while greatly increasing research capabilities.

    It is the largest of its kind in Australia and one of just two SimVitro robots in the country.

    Director of the Kolling’s Murray Maxwell Biomechanics Lab Associate Professor Elizabeth Clarke has welcomed its installation, saying it represents a significant step for orthopaedic and biomedical engineering research, new surgical techniques and medical technologies.

    “KOBRA will be used to simulate complex human movements on joints. This is a new way of working and very few other machines have this capability where they can test joints through a broad range of life-like manoeuvers, like hip flexing, squatting, walking and throwing.

    “We expect to use the robot in the testing of implants, particularly for hip and knee replacements, to gauge how the implants will function and to help ensure the movement is as life-like as possible,” Associate Professor Clarke said.

    The orthopaedic biomechanics robotic is not only expected to advance hip and knee replacements, but is also likely to assist surgeons working to repair chronic shoulder instability. Large numbers of patients are presenting with this injury and the information provided by the robot will help to improve the quality of research and optimise surgical approaches.

    Professor Bill Walter, Royal North Shore Hospital orthopaedic surgeon and Professor of Orthopaedics and Traumatic Surgery at the University of Sydney has witnessed advances in surgical techniques over many years.

    He said the next improvements will be delivered through new technologies provided by robots like KOBRA.

    “We have seen that previous innovations have come through new materials and design. The next innovations however in joint replacement surgery will be delivered through improved biomechanics of the artificial joints,”

    “It’s tremendously encouraging to see this world-leading technology coming to the Kolling. It will assist researchers, engineers and surgeons, and ultimately lead to improved surgical techniques, better placement of implants and good long-term health outcomes for our community.”

    The robot has been made possible following a collaboration between the Northern Sydney Local Health District, the University of Sydney, the Kolling Institute, the NSW Investment Boosting Business Innovation program and the RNSH Staff Specialist Trust Fund. 

  • Kolling researchers present at international congress

    Kolling researchers present at international congress

    Kolling Institute researchers have helped map out exciting future developments for the rehabilitation of hip and knee replacement patients.

    A team of researchers from Sydney Musculoskeletal Health – a partnership between the University of Sydney, Sydney Local Health District and Northern Sydney Local Health District – recently attended the International Society for Technology in Arthroplasty’s annual congress in Hawaii.

    As well as meeting up and sharing ideas with professionals from across the globe, team members gave several presentations detailing their research in the area of technologies in arthroplasty.

    Bill Walter, Professor of Orthopaedics and Traumatic Surgery at the University of Sydney and Royal North Shore Hospital, led the team at the congress and said it had been a rewarding experience.

    “You have the world’s greatest concentration of expert knowledge in this area,” he said. 

    “It’s very exciting meeting people trying to resolve some of the problems facing hip and knee replacement patients.”

    Presentations at the event included the exploration of developing technologies such as Artificial Intelligence, how wearable devices can assist with patient monitoring and advancements in robotics and smart instruments.

    Presentations by the team included their work investigating ceramic hip resurfacing and examining the bio-mechanics of hip and knee replacements and spinopelvic issues.

    The Sydney Musculoskeletal Health Team, whose Kolling researchers are based at RNSH, works with leaders in health on research, clinical services and training.

    About 1.7 billion people worldwide have musculoskeletal conditions. Low back pain, osteoarthritis, neck pain, rheumatoid arthritis and gout are some of the major musculoskeletal disorders and are one of the leading contributors to disability worldwide.

    The annual conference, which was established in 1988, is attended by hundreds of surgeons, scientists, engineers and industry representatives from across the world to advance the technology in arthroplasty.

    “It’s great to be part of this event because it’s a place where you find and meet like-minded people from across the world who ultimately are trying to improve the quality of life for patients in this area,” Professor Walter, a former ISTA President, said.

    “It’s a privilege to be involved.”

  • World Arthritis Day directs focus to the latest research and clinical trial opportunities

    World Arthritis Day directs focus to the latest research and clinical trial opportunities

    Arthritis is the third most prevalent long-term health condition in Australia affecting more than 12 per cent of Australians.

    There is no cure for arthritis, with treatment options largely focused on alleviating pain, including pain relief medication, arthroscopy or joint replacement.

    Australia is at the forefront of clinical research and trials, which is helping the community better manage their arthritis.

    Leading rheumatology clinician researcher Professor David Hunter and Arthritis Australia CEO Jonathan Smithers say it’s important for people to know about their arthritis and how to manage it, and be across studies and trials they may be able to take part in.

    EPIPHA-KNEE trial

    Although sounding contradictory to people with joint pain, physical activity has well established benefits for knee osteoarthritis. However, 90% of people with osteoarthritis don’t meet physical activity guideline recommendations or walk regularly for exercise.

    To better assess the benefits of exercise, the Epipha-knee trial involving nearly 200 people will investigate physiotherapist-led walking, strengthening, and education programs. One group of subjects will receive additional education about osteoarthritis pain and activity to improve their knowledge.

    The trial aims to determine whether the addition of physiotherapist-delivered pain science education is more effective than simply undertaking the individualised program alone.

    Full details and how to register: 

    SCUlpTOR study

    Professor Hunter is leading a 440-person trial into the potential modification of osteoarthritis using mesenchymal stem cells (MSCs) in people over 40 with osteoarthritis in their knees, and who have lived with moderate plus pain for several years.

    Australian stem cell company Cynata Therapeutics is supplying the MSCs for the trial and CEO Dr Ross Macdonald says the trial is one of the world’s largest investigating the use of stem cells for osteoarthritis. “It’s a gold-standard study: a randomised, double-blind, placebo controlled clinical trial designed to discover whether stem cell injections in the knee improve symptoms and slow disease progression to improve underlying disease and therefore quality of life,” he said.

    Full details and registration: 

    Unsupervised online yoga

    We did a lot of it in lockdown and according to a 212-person trial, a 12-week online unsupervised yoga program improved knee stiffness and quality of life. However, the yoga didn’t improve knee pain, nor was it sustained at 24 weeks.

    Therefore, those with osteoarthritis of the knee should still consider other forms of pain management.

    Full study details:   

    Thumb Base Osteoarthritis

    They certainly get a workout as our smartphone addiction grows, and a randomised, parallel trial which compared conservative treatments with an education comparator found that combined treatments improve hand function.

    This 204-person trial split participants with half receiving education on self-management and ergonomic principles, a base-of-thumb splint, hand exercises, and Voltaren 1%, gel. The comparator group received education on self-management and ergonomic principles alone.

    The combination intervention led to improvements in both pain and function compared to education alone.

    Full study details:    

    My Joint Pain

    Education is key, so Arthritis Australia has developed a comprehensive online hub to help people manage their joint pain and live a more active and pain free life. An evaluation of My Joint Pain, found improvements in self-management, lifestyle, and weight reduction.

    Arthritis Australia CEO Jonathan Smithers says “We know that people living with osteoarthritis want more information and options to manage their condition. My Joint Pain includes a wealth of free, evidence-based resources to help consumers live well with arthritis.”

    Users can register with My Joint Pain to undergo a personalised risk assessment, find information tailored to their needs and access a personalised management plan that includes resources on medication, exercise, diet, lifestyle choices, pain management and healthcare providers.

    Registered users can also manage and track their osteoarthritis over time by answering weekly questions to see how they are progressing.

  • New Academic Director shares vision for research success

    New Academic Director shares vision for research success

    Ambitious leadership, functional wellbeing and a passion for collaboration

    An international healthcare destination celebrated for its collaborative spirits and dedication to human health and wellbeing. This is Professor Jim Elliott’s vision for how the collaboration between the Kolling Institute, the Faculty of Medicine and Health and the Northern Sydney Local Health District will evolve.

    Highly respected in the global research community, Professor Elliott was recently appointed the Kolling Institute’s Academic Director. His past careers in professional baseball, physiotherapy and research academia have offered Jim a wealth of wisdom to draw from and have shaped his positive, enthusiastic and empathetic mindset. When listing the advice he has picked up along the way, he includes, “Do simple better” and “Be present, not perfect.”

    Common goals
    In his new role, Jim will work towards the shared strategic goals of the Kolling, the Faculty of Medicine and Health and the NSLHD. These goals also align with the Northern Health Precinct model, leveraging the strength of joint-venture partners and enabling all to reach shared goals. Jim understands that “we share a common vision to support world-leading translational research, increase our research impact and consistently improve health outcomes.”

    In his new role, Jim looks forward to working collaboratively “inside and outside the building” to address and report against the growth and sustainability of the Kolling Institute.

    From his days as a professional baseballer, Jim applies the advice, “Don’t give folks an opportunity to misquote you in the press.” He believes that having a clear and consistent media and communications strategy is crucial for internal and external facing messaging, which also supports the recruitment and retainment of new high-flying faculty, clinical staff and students.

    Together, we will determine how our impact will be measured, recorded, and shared through a strategic and wide-reaching communications plan. Our approach will work towards ensuring the Kolling Institute is an international healthcare destination – one that the NSLHD and the faculty can be proud of.

    Jim’s experience as a Professor of Allied Health makes it feel like a natural fit for him when it comes to putting the Northern Health Precinct’s key theme of Functional Wellbeing into action. Wellbeing represents a complex combination of physical, mental, emotional and social health and is strongly linked to happiness and life satisfaction. Additionally, allied health professionals offer a broad range of diagnostic, technical, therapeutic and direct health services to improve the health and wellbeing of the patients they work with.

    Jim’s vision
    Jim’s respect for interdisciplinary collaboration has grown following a career as a research academic trained as a physiotherapist.

    In short, our successes are a sum of all the parts and that goes a long way towards translation of research into clinical practice where it can positively influence patient-outcomes on a patient-by-patient basis. This requires trusting and productive collaboration between our medical, nursing and allied health colleagues.

    Jim highlights that traditional models of healthcare are delivered and evaluated in isolation, where patients are expected to seek individual services with little or no collaboration between healthcare providers. He recognises that the current health professional educational models, which operate the same way, as unintentional contributors to the development and maintenance of siloed areas of health. They reinforce the lack of valuable interdisciplinary collaboration between staff and students from various professions.

    Jim hopes to meet the need for developing new models of student and staff interaction, education, clinician research pathways and patient service delivery through creating best-practice interdisciplinary student placements. These models will aim to enhance functional wellbeing with the ability to be delivered across a range of settings and populations.

    He predicts that by leveraging the strengths, resources and expertise of the Kolling Institute, the Faculty of Medicine and Health and the NSLHD, we will be well placed to expand our research success.

    This approach will help position us as global leaders in health and medicine, and ensure we deliver research outcomes that ultimately improve the care our community members receive.

    The innovative and diverse nature of this partnership delivers best-practice interdisciplinary models of education and care-pathways by which the NSLHD, the University, NSW TAFE and our local community members can work together.

    A passionate HDR Supervisor
    Among a remarkable list of achievements, Jim has directly improved health practices around neck pain, broadened our understanding of whiplash injuries and embraced cutting-edge technology to progress research in the complex trauma and pain fields. Jim remembers when a clinical mentor of his quoted renowned nurse, Margo McCaffery, ‘Pain is whatever the experiencing person says it is, existing whenever and wherever the experiencing person says it does’. “To me, if we are to believe McCaffery’s statement (and I do), then it means the patient is the closest thing to a gold-standard measure of pain there is,” he adds.

    Jim’s career in research academia and collaborative spirit is influenced by the African proverb, “If you want to go fast, go alone. If you want to go far, go together.” When reminiscing on his favourite memory since joining the University, he recalls when his first PhD student, Dr Danielle Stone, Speech Pathologist at Royal North Shore Hospital, enrolled in 2019. “In the blink of an eye, she received word she had been recommended for the award of the degree of Doctor of Philosophy, WITHOUT FURTHER CONDITIONS!”

    It was very pleasing to witness Danielle’s growth and development in this interdisciplinary environment and the respect she gained from her team. It is also noteworthy, that Danielle completed her PhD studies in the university timeline while working clinically as a speech pathologist at Royal North Shore Hospital and is a mum of three young children.

    Danielle’s thesis, Dysphagia, Dysphonia, and Laryngeal Hypersensitivity following Whiplash, brought together an international team of leading research academics from Speech Pathology, Physiotherapy, Magnetic Resonance Physics, Genetics and Molecular Biology, and Psychology.

    “A true interdisciplinary collaborative,” as Jim hails it, making it only fitting that he respectfully quotes Ginger Rogers as some of the most important advice he’s learnt, “I did everything Fred Astaire did, backwards and in heels.”

  • Researchers to study link between cardiovascular disease and sleep apnoea

    Researchers to study link between cardiovascular disease and sleep apnoea

    With a disturbing number of people losing their lives to heart disease each year, researchers have launched the first study of its kind using MRI technology to broaden our understanding of the link between cardiovascular disease and sleep apnoea.

    The project has been made possible following funding from the Ramsay Research Grant Program, and will involve clinician researchers from Northern Sydney Local Health District and the University of Sydney.

    It follows the latest figures showing cardiovascular disease is the leading cause of death worldwide, killing one Australian every 12 minutes.

    This makes the research important and timely, especially given that obstructive sleep apnoea is also increasing, and is now affecting around a billion people. Known as the silent killer, this chronic disease causes low oxygen levels, sleep disturbance and dangerous pressure inside the chest.

    Royal North Shore Hospital respiratory and sleep medicine specialist Professor Peter Cistulli will lead the study, collaborating with RNSH Head of Respiratory and Sleep Medicine Dr Ben Harris, and Kolling Institute researchers Professor Martin Ugander and Dr Rebecca Kozor, who are experts in cardiac imaging. 

    Professor Cistulli said obstructive sleep apnoea has been linked to the development of cardiovascular disease, including hypertension, heart attack, atrial fibrillation and stroke – but there have been no randomised controlled trials confirming a causal link between the two.

    “Our CardioSleep Program will be unique, uniting three major disciplines of cardiology, respiratory and sleep medicine, and radiology to develop a precision medicine approach. This would define which patients are at greatest risk and require personalised treatment,” he said.

    “We hope our project will provide definitive evidence of the relationship between sleep apnoea and cardiovascular disease, closing our existing gaps in knowledge and informing future treatment approaches.

    “We would like to see this valuable research program drive a new approach, and one which will dramatically reduce the number of number of people who lose their lives prematurely with a combination of sleep apnoea and cardiovascular disease.”

  • Funding paves the way for crucial new research programs

    Funding paves the way for crucial new research programs

    A large collection of research projects will get underway at Royal North Shore Hospital following generous funding through the Ramsay Research Grants Program.

    The scheme has directed more than $10 million to research on the campus over the last 19 years.

    This year over $700,000 is being invested in a total of 14 innovative studies, all aimed at improving our research impact and the care delivered to our community.

    A diverse range of projects have received backing, including studies investigating cancer treatment, renal transplant care and the link between cardiovascular disease and sleep apnoea.

    Researchers will also examine new techniques to reduce pain, biomarkers for MS and programs to help clinicians identify and care for those with Fetal Alcohol Spectrum Disorder.

    One of the studies will investigate support for adolescents with diabetes as they transition from paediatric to adult services.

    Study lead Dr Shihab Hameed said this is often a very challenging time, marked by a deterioration in health and a loss of contact with treating teams.

    “Managing the condition requires a big commitment from patients to prevent long-term problems such as blindness, kidney failure, heart attacks, or early death, so it’s important to especially support young people as they become more independent and move into adult services,” he said.

    “Our project has the potential to substantially improve the health of young adults at this critical junction in their lives, and provide lifelong benefits by preventing irreversible damage.”

    Researchers will also launch a study to gain a better understanding of the perception of the medical forensic examination following a recent sexual assault.

    This will be from the point of view of patients who attend the district’s sexual assault service, victim-survivors who may not have presented to a service and the general population.

    Principal investigator Dr Mary Stewart said with sexual assault reports increasing, it is more important than ever that we ensure we are providing the care that victim-survivors need and that there’s a greater awareness of the services provided.

    “We hope to demonstrate the benefits of presenting for a health response after sexual assault, including the medical and psychosocial care and an optional forensic service. We also aim to identify the barriers to presenting after sexual assault so that these can be addressed.”

    A further study will assess a digital behavioural pain management intervention to improve pain relief and reduce a reliance on opioids in patients with rib fractures.

    Director of Acute Pain Services Associate Professor Damien Finniss said opioids are a key component of acute pain management, yet there are risks associated with over-reliance, particularly when patients transition from hospital to the community.

    “We know that patients who engage with behavioural pain management strategies have improved pain relief and show reduced reliance on opioids, so we expect that this low-cost intervention will help patients with pain transition more safely to the community.” 

  • High-profile clinician researcher recruited to key research position

    High-profile clinician researcher recruited to key research position

    Professor Bruce Robinson has been appointed the NSLHD Chair of Research in an important step towards strengthening research expertise across the district.

    Professor Robinson, a Kolling Institute researcher, will step into the newly created role this month, bringing a tremendous wealth of research, clinical and policy experience with him.

    Bruce will be responsible for providing leadership and strategic advice, while also driving the implementation of the NSLHD Research Strategy and other major research projects across NSLHD hospitals and services.

    Chief Executive Deb Willcox welcomed the appointment saying Bruce will be charged with delivering innovation across NSLHD as well as the broader research community.

    “I would like to thank Bruce for taking on this important new role and for sharing his expertise to bolster our research success. Ultimately, it will improve the care we provide,” she said.

    “There are few people with Bruce’s credentials. He has had a clinical, research, academic and executive career spanning more than three decades and is highly respected across the national and international community.

    “As a leading endocrinologist at RNSH, Bruce has influenced clinical care practices, led large-scale research projects, and informed national health programs.

    “He has held a large number of senior positions across health, academia and business, and his extraordinary contribution has been recognised with a host of awards, including a prestigious Companion of the Order of Australia.

    “Bruce will bring a unique perspective to the position and will work to ensure our research increasingly influences national and international health policy and practice.”

    Professor Robinson said he was excited to move into the role and was looking forward to building on the existing research strengths across the campus.

    “Initially, I’ll be consulting with a large number of our research community to confirm our areas of expertise and identify a unifying theme for the district,” he said.

    “This will be an important step towards cementing our place as a district of research excellence, where evidenced-based projects inform and improve the delivery of our care.

    “As we work to raise our profile, I would like to see greater community involvement and engagement in our research so that our projects reflect the needs of the broader community.

    “I would also like to see greater connection with Sydney Health Partners to maximise the benefits of the partnership for our district.

    “Strengthening our internal and external collaborations will be key to our research progress. By leveraging these partnerships, our research team will be better placed to increase the impact of their work and improvements in healthcare.”

  • Researchers develop test to identify the severity of kidney disease

    Researchers develop test to identify the severity of kidney disease

    We may soon have a safer approach to diagnosing and measuring the progression of chronic kidney disease following new research by the team from the Kolling Institute’s Renal Research Laboratory.

    The condition is a global health issue, which now affects more than 13 per cent of the worldwide population.

    Chronic kidney disease is a progressive disease that leads to end-stage kidney failure, which is fatal without dialysis or a kidney transplant.

    Currently there are tests to detect advanced stages of the disease, but early detection is not possible.

    Biopsies are performed to confirm a diagnosis of chronic kidney disease, but this approach brings with it inherent risks such as bleeding, pain and hospitalisation.

    Encouragingly, researchers from the Kolling Institute and the University of New South Wales have now developed biomedical technology to provide accurate information around early diagnosis and prognosis, without the risks of an invasive biopsy procedure.

    Head of the Kolling’s Renal Research Laboratory Professor Carol Pollock said this exciting new technology provides clear information about kidney pathology by examining kidney cells in urine.

    “Having the ability to diagnose patients with a simple urine test represents a significant step forward for those with chronic kidney disease,” she said.

    “Importantly, this enables early intervention and effective management.”

    Project co-lead Associate Professor Sonia Saad said that being able to assess kidney pathology in a non-invasive way brings a host of benefits.

    “It will enable clinicians to examine the effects of new drugs on the kidney and monitor kidney pathology over time. This will provide valuable information on the effectiveness of treatments.”

    PhD student Dr Henry Wu has welcomed the chance to be involved in the project.

    “It’s been rewarding to have been part of the development of this important new technology. We would like to see it applied broadly across clinical practice given the health and economic benefits of this approach,” he said.

    The study is being led by Professor Pollock and Associate Professor Saad from the University of Sydney in collaboration with Professor Ewa Goldys and her team from the University of New South Wales.

  • Researchers seeking closer ties with industry

    Researchers seeking closer ties with industry

    Researchers at the Kolling Institute are increasingly forging partnerships with industry, with the collaborative efforts accelerating improvements in patient care.

    One team which has particularly benefitted from a strong relationship with industry partners is the diverse group from the Murray Maxwell Biomechanics Laboratory.

    Director, Associate Professor Liz Clarke is encouraging others to follow suit, convinced that collaborations with business bring vast opportunities and benefits for researchers.

    “Our partnerships with Allegra Orthopaedics and Bone Ligament Tendon have delivered more than $3 million in funding, on top of crucial employment, education and training opportunities for a large collection of researchers,” she said.

    “Industry ties offer a chance to develop intellectual property for products, while also raising the profile of teams and their expertise. This can lift your reputation not just nationally but internationally as well.

    “Our business partnerships have delivered a wealth of support to our team and it all stemmed from a small industry-led research project several years ago.

    “We were then involved with extensive testing of a kangaroo xenograft for ACL injuries, as well as the product development of a device to help manage problems with spinal discs. Significant progress has been made with both of these projects.

    “Each opportunity brought more funding, more jobs and more chances for our younger researchers to advance their careers.

    “I’ve welcomed the chance to work with our partners on real world problems, where we have brought together experts from business, academia and health, to accelerate the translation of research and deliver tangible improvements in medical technologies and patient care.

    “It’s been a supportive environment and tremendously encouraging to see consistent and timely progress. This is helping to speed up the time it takes to bring advances to patient care, broadly improving the health of our community.

    “I anticipate we will see an escalation in partnerships with industry with the Kolling well-positioned to take advantage of upcoming opportunities. Our researchers have a unique breadth of experience and expertise, along with access to world-leading technology.”

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