Academic Psychiatry and CADE Clinic

Research in psychiatry is integrated into clinical practice, and involves a number of academic and clinical psychiatry groups. It spans mood disorders, consultation liaison psychiatry and drug and alcohol services. A good example of this integration is the CADE Clinic, which is embedded within the Department of Academic Psychiatry. The clinic is a state-wide specialist service that is based at Royal North Shore Hospital. As part of the Northern Sydney Local Health District, the University of Sydney and Kolling Institute, the clinic acts as a hub for clinical research and education.

In practice, the service addresses the needs of patients suffering from complex mood disorders and is managed by Professor Malhi and his dedicated team of researcher-clinicians.


Lead

Professor Gin Malhi MB ChB, MD, FRCPsych, FRANZCP.

Psychiatry Chair, Northern Clinical School

The CADE Clinic team comprises clinicians and experienced researchers with diverse skill sets including clinical and neurocognitive assessment and the sophisticated analysis of neuroimaging data.

Dr Pritha Das PhD

Senior Research Fellow
Psychiatry, Northern Clinical School

Dr Zola Mannie PhD

Senior Research Fellow

The CADE team has developed strong national and international collaborations involving world-renowned experts. In addition to contributing directly to research, these international networks have been key in the development of national guidelines for the management of mood disorders – impacting policy-making nationally and internationally via the World Health Organization.

  • The research team makes use of clinical and neuropsychological assessments in conjunction with functional neuroimaging (fMRI) to investigate the neural basis of mood disorders in adolescents and adults.
  • Recent research has focused on understanding the emergence of mood disorders and the prevention of suicide. Interest has been especially centred on determining the potential role of lifestyle and psychological therapies.
  • The team is also interested in understanding the mechanisms of action of pharmacological therapies, such as lithium and in particular, it’s neuroprotective properties.

Aims

  • The thrust of our research is the investigation of mechanisms, and our research is aimed at identifying the processes that drive adaptive resilience.
  • Identify the neural signature of suicidal thinking and behaviour to develop target-specific initiatives that can prevent suicide.

The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders https://www.ranzcp.org/files/resources/college_statements/clinician/cpg/mood-disorders-cpg-2020.aspx

The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders: Major depression summary https://doi.org/10.1111/bdi.13035

The 2020 Royal Australian and New Zealand College of psychiatrists clinical practice guidelines for mood disorders: Bipolar disorder summary https://doi.org/10.1111/bdi.13036

https://www.sydney.edu.au/medicine-health/about/our-people/academic-staff/gin-malhi.html#profile

https://www.sydney.edu.au/medicine-health/about/our-people/academic-staff/pritha-das.html#profile

https://www.researchgate.net/profile/Zola-Mannie-3

Bell E, Boyce P, Porter RJ, et al. (2020) Could irritability be the key to unlocking the enigma of mixed states? Bipolar Disorders 22: 781-784.

Bell E, Bryant RA, Boyce P, et al. (2021) Irritability through Research Domain Criteria: an opportunity for transdiagnostic conceptualisation. BJPsych Open 7: e36.

Bell E and Malhi GS. (2020) Irritability: An inability, or an ability? Australian and New Zealand Journal of Psychiatry 54: 1232-1233.

Malhi G, Bell E, Das P, et al. (2019a) Relating irritability and suicidal ideation using mood and anxiety. Evidence-Based Mental Health 22: 95-99.

Malhi GS, Bell E, Mannie Z, et al. (2020a) Attempting suicide changes the brain? Australian and New Zealand Journal of Psychiatry 54: 7-9.

Malhi GS, Das P, Bell E, et al. (2019b) Understanding trauma-induced hippocampal subfield volume changes in the context of age and health. Journal of Affective Disorders 257: 150-151.

Malhi GS, Das P, Bell E, et al. (2019c) Modelling resilience in adolescence and adversity: a novel framework to inform research and practice. Translational Psychiatry 9.

Malhi GS, Das P, Outhred T, et al. (2020b) Hippocampal volumes and resilience in adolescent girls exposed to emotional trauma. Acta Psychiatrica Scandinavica 141: 84-87.

Malhi GS, Das P, Outhred T, et al. (2019d) Resting-state neural network disturbances that underpin the emergence of emotional symptoms in adolescent girls: resting-state fMRI study. British Journal of Psychiatry 215: 545-551.

Malhi GS, Das P, Outhred T, et al. (2020c) Role of self-focussed reappraisal of negative emotion in emergence of emotional symptoms in adolescent girls. British Journal of Psychiatry 217: 383-389.

Malhi GS, Das P, Outhred T, et al. (2020d) Interactions of OXTR rs53576 and emotional trauma on hippocampal volumes and perceived social support in adolescent girls. Psychoneuroendocrinology 115.

Malhi GS, Das P, Outhred T, et al. (2019e) Effect of stress gene-by-environment interactions on hippocampal volumes and cortisol secretion in adolescent girls. Australian and New Zealand Journal of Psychiatry 53: 316-325.

Malhi GS, Das P, Outhred T, et al. (2019f) Cognitive and emotional impairments underpinning suicidal activity in patients with mood disorders: an fMRI study. Acta Psychiatrica Scandinavica 139: 454-463.

Malhi GS, Das P, Outhred T, et al. (2019g) The effects of childhood trauma on adolescent hippocampal subfields. Australian and New Zealand Journal of Psychiatry 53: 447-457.

Malhi GS and Mann JJ. (2018) Depression. The Lancet 392: 2299-2312.

Malhi GS, Outhred T, Das P, et al. (2018) Modeling suicide in bipolar disorders. Bipolar Disorders 20: 334-348.

McIntyre RS, Berk M, Brietzke E, et al. (2020) Bipolar disorders. The Lancet 396: 1841-1856.

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