The Department of Academic Psychiatry and CADE Clinic is dedicated to understanding the causes and mechanisms that underpin mood disorders such as depression and bipolar disorder, and their consequences such as suicide. The primary aim of our translational studies is to prevent mood disorders and suicide through better understanding and optimal treatment. The department employs a multidisciplinary approach integrating clinical research and basic neuroscience.
The CADE Clinic and Mood-T Service is a state-wide specialist service that is based at Royal North Shore Hospital. CADE stands for Clinical Assessment and Diagnostic Evaluation, named after John Cade, the Australian Psychiatrist who pioneered the use of lithium for the treatment of bipolar disorder. As part of the Northern Sydney Local Health District and in collaboration with the University of Sydney and Kolling Institute, the clinic acts as a hub for clinical research and education.
The research outcomes from the Department of Academic Psychiatry and CADE Clinic have informed the Australian and New Zealand guidelines for mood disorders, The Sydney Medical School Textbook of Psychiatry and seminal articles within internationally esteemed journals such as The Lancet, The British Journal of Psychiatry and Bipolar Disorders. For further information including research outputs see: www.cadeclinic.com
Team Lead
Professor Gin Malhi
Psychiatry Chair, Northern Clinical School
CADE Clinic
Team Members
Dr Zola Mannie
Postdoctoral Scientist
Amber Hamilton
Research Administration Officer
Grace Marks
MD Research Project Student
Erica Bell
PhD Student
https://www.cadeclinic.com/poetstudy
- This naturalistic study is examining the clinical translation of esketamine as a treatment for depression that has not responded to conventional treatments. This naturalistic study aims to understand the clinical and illness profile of patients for whom esketamine will be most effective.
- Translation of research and clinical findings into educational resources for clinicians, students, patients and young people.
- The Early Accurate Specialist Treatment Enabling Recovery (EASTER) research study aims to investigate how common psychiatric illnesses can be detected and prevented in young people.
- An evidence synthesis project in collaboration with the University of Oxford and supported by Wellcome.
National
- Janssen Australia
- Greek Young Matrons’ Association (GYMA)
International
- American Foundation for Suicide Prevention
- Columbia University, United States
- University of Oxford
- Wellcome Foundation
- National Taiwan University
- International Society for Bipolar Disorders (ISBD)
- SNEHA (A volunteer organisation for suicide prevention in India)

