{"id":2678,"date":"2025-09-17T15:06:49","date_gmt":"2025-09-17T05:06:49","guid":{"rendered":"https:\/\/webdev.sydney.edu.au\/kolling\/research-group\/sutton-arthritis-research-laboratory\/"},"modified":"2026-07-30T13:37:45","modified_gmt":"2026-07-30T03:37:45","slug":"sutton-arthritis-research-laboratory","status":"publish","type":"research-group","link":"https:\/\/kollinginstitute.org.au\/news_demo\/research-group\/sutton-arthritis-research-laboratory\/","title":{"rendered":"Sutton Arthritis Research Laboratory"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull has-white-background-color has-background is-layout-flow wp-block-group-is-layout-flow\" style=\"padding-top:0;padding-bottom:0\">\n<div style=\"margin-top:0;margin-bottom:0;padding-top:0;padding-bottom:0;--etb-a-tab-btn-bg-color:#007ed5;--etb-a-tab-btn-text-color:#FBFAF3;--etb-a-tab-btn-heading-color:#FFFFFF;--etb-a-tab-image-filter:none;--etb-a-tab-bt-style:none;--etb-a-tab-bt-width:0px;--etb-a-tab-br-style:none;--etb-a-tab-br-width:0px;--etb-a-tab-bb-style:none;--etb-a-tab-bb-width:0px;--etb-a-tab-bl-style:none;--etb-a-tab-bl-width:0px;--etb-h-tab-btn-bg-color:color-mix(in srgb, currentColor 20%, transparent);--etb-h-tab-btn-text-color:#FBFAF3;--etb-h-tab-image-filter:none;--etb-h-tab-bb-color:#ab40a1;--etb-h-tab-bb-width:2px\" class=\"wp-block-easy-tabs-block-tabs has-active-etb-bg-color has-active-etb-text-color has-active-etb-heading-color has-active-etb-border has-active-etb-duotone has-hover-etb-bg-color has-hover-etb-text-color has-hover-etb-border  false\" data-id=\"15dcc441-9734-467a-b5cc-e31f82dca9f0\" data-initial-tab=\"1\" data-trigger=\"click\" data-accessibility=\"true\"><div class=\"wp-block-easy-tabs-block-tabs-inner is-layout-flow wp-block-easy-tabs-block-tabs-is-layout-flow\">\n<div class=\"etb-tabs-buttons-scrollable-with-arrows wp-container-content-9cfa9a5a\"><div class=\"wp-block-easy-tabs-block-tab-buttons has-etb-buttons-scrollable has-small-font-size is-content-justification-left is-layout-flex wp-container-easy-tabs-block-tab-buttons-is-layout-1a549490 wp-block-easy-tabs-block-tab-buttons-is-layout-flex\" style=\"border-bottom-color:var(--wp--preset--color--accent-6);border-bottom-width:1px;padding-top:0;padding-bottom:0\" data-selector=\"15dcc441-9734-467a-b5cc-e31f82dca9f0\" role=\"tablist\">\n<button class=\"wp-block-easy-tabs-block-tab-button has-text-color has-link-color wp-elements-29bc920b546c3ab7d32a99fcb9dae9d4\" style=\"color:#101827\" data-selector=\"15dcc441-9734-467a-b5cc-e31f82dca9f0\" id=\"4e2e1331-aeba-43aa-9a7c-07a74e2c1017\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab-4e2e1331-aeba-43aa-9a7c-07a74e2c1017\" tabindex=\"-1\">\n<h2 class=\"wp-block-heading has-contrast-color has-text-color has-link-color has-medium-font-size wp-elements-ff56fb5b180573e3245b4ec13836c990\" style=\"margin-top:0;margin-bottom:0;padding-top:0;padding-bottom:0\">About us<\/h2>\n<\/button>\n\n\n\n<button class=\"wp-block-easy-tabs-block-tab-button has-contrast-color has-text-color has-link-color wp-elements-dcc3457aeecf2e9ca09c8535d583598f\" style=\"font-size:clamp(14px, 0.875rem + ((1vw - 3.2px) * 0.185), 16px);font-style:normal;font-weight:600;line-height:1.5\" data-selector=\"15dcc441-9734-467a-b5cc-e31f82dca9f0\" id=\"64049a74-c3ff-46b3-bedc-3776ee0c7a98\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab-64049a74-c3ff-46b3-bedc-3776ee0c7a98\" tabindex=\"-1\">\n<h2 class=\"wp-block-heading has-medium-font-size\">Our Team<\/h2>\n<\/button>\n\n\n\n<button class=\"wp-block-easy-tabs-block-tab-button has-contrast-color has-text-color has-link-color wp-elements-64c179bfd75c2c242877d5ec0bfaaf5c\" style=\"font-size:clamp(14px, 0.875rem + ((1vw - 3.2px) * 0.185), 16px);font-style:normal;font-weight:600;line-height:1.5\" data-selector=\"15dcc441-9734-467a-b5cc-e31f82dca9f0\" id=\"1fb17064-c4f9-417c-9167-cad2cd809405\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab-1fb17064-c4f9-417c-9167-cad2cd809405\" tabindex=\"-1\">\n<h2 class=\"wp-block-heading has-medium-font-size\">Projects<\/h2>\n<\/button>\n<\/div><button class=\"etb-scroll-button left\" aria-label=\"Scroll to the left\"><span class=\"chevron-left\"><\/span><\/button><button class=\"etb-scroll-button right\" aria-label=\"Scroll to the right\"><span class=\"chevron-right\"><\/span><\/button><\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-contents\" style=\"border-style:none;border-width:0px\">\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-fade\" data-selector=\"15dcc441-9734-467a-b5cc-e31f82dca9f0\" id=\"tab-4e2e1331-aeba-43aa-9a7c-07a74e2c1017\" aria-labelledby=\"4e2e1331-aeba-43aa-9a7c-07a74e2c1017\" role=\"tabpanel\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-right:var(--wp--preset--spacing--60);flex-basis:70%\">\n<p class=\"wp-block-paragraph\">The Kolling Institute, Northern Clinical School, Faculty of Medicine and Health, University of Sydney&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Founded in 1961, the Sutton Lab is Australia\u2019s first laboratory dedicated to researching inflammatory arthritis. We focus primarily on rheumatoid arthritis, a condition that affects 2% of Australians, nearly half of whom still lack adequate treatment. For over six decades, our mission has remained the same: to move beyond simply managing symptoms and find ways to prevent and cure the disease.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Our Work&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Discovering Targets and Biomarkers:<\/strong> We identify and test new biological markers and treatment targets to help detect the disease earlier and tailor therapies to individual patients.\u00a0\u00a0\u00a0<\/li>\n\n\n\n<li><strong>Translating Research into Medicine:<\/strong> We bridge the gap between laboratory science and patient care. By taking laboratory discoveries, such as new proteins that stop or prevent joint damage, we work to turn them into practical therapies for patients and healthcare systems.&nbsp;<\/li>\n\n\n\n<li><strong>Leading Biobanking Efforts:<\/strong> We serve as the operational headquarters for the Australian Arthritis and Autoimmune Biobank Collaborative. This is Australia\u2019s first open-access biobank network dedicated entirely to musculoskeletal diseases.\u00a0<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"780\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/Picture4-2-1024x780.jpg\" alt=\"\" class=\"wp-image-7304\" srcset=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/Picture4-2-1024x780.jpg 1024w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/Picture4-2-300x229.jpg 300w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/Picture4-2-768x585.jpg 768w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/Picture4-2.jpg 1435w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\">\n<div class=\"wp-block-cover has-aspect-ratio\" style=\"min-height:30vh;aspect-ratio:1;min-height:unset;\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" class=\"wp-block-cover__image-background wp-image-7459 size-full\" alt=\"\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2026\/07\/Kolling-PRA-Tiles_600x600px_MandR.jpg\" data-object-fit=\"cover\" srcset=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2026\/07\/Kolling-PRA-Tiles_600x600px_MandR.jpg 600w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2026\/07\/Kolling-PRA-Tiles_600x600px_MandR-300x300.jpg 300w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2026\/07\/Kolling-PRA-Tiles_600x600px_MandR-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-black-background-color has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<div class=\"wp-block-group is-vertical is-content-justification-center is-layout-flex wp-container-core-group-is-layout-1af4f3bb wp-block-group-is-layout-flex\" style=\"min-height:20vh\">\n<p class=\"has-text-align-center has-base-color has-text-color has-link-color has-lora-font-family wp-elements-5d1efe4791a5fe7a1162bee37fd36c11 wp-block-paragraph\" style=\"padding-top:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30);font-size:clamp(18.959px, 1.185rem + ((1vw - 3.2px) * 1.022), 30px);font-style:normal;font-weight:300\">Musculoskeletal and Rehabilitation<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-nowrap is-layout-flex wp-container-core-buttons-is-layout-f8f67980 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100\"><a class=\"wp-block-button__link has-base-color has-text-color has-background has-link-color has-border-color has-base-border-color wp-element-button\" href=\"https:\/\/kollinginstitute.org.au\/musculoskeletal-research\/\" style=\"border-width:2px;border-radius:30px;background-color:#00a896;padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--70);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--70)\">Find out more<\/a><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-fade\" data-selector=\"15dcc441-9734-467a-b5cc-e31f82dca9f0\" id=\"tab-64049a74-c3ff-46b3-bedc-3776ee0c7a98\" aria-labelledby=\"64049a74-c3ff-46b3-bedc-3776ee0c7a98\" role=\"tabpanel\">\n<div class=\"wp-block-group has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-7b3b4a3b wp-block-group-is-layout-constrained\" style=\"background-color:#0000000d;margin-top:var(--wp--preset--spacing--70);margin-bottom:var(--wp--preset--spacing--70);padding-top:var(--wp--preset--spacing--50);padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50);padding-left:var(--wp--preset--spacing--50)\">\n<h3 class=\"wp-block-heading has-contrast-color has-text-color has-link-color wp-elements-0df2b60564b8e462012545eec83a1e36\">Team Lead<\/h3>\n\n\n    <div class=\"team-block-page is-single-lead\">\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"233\" height=\"300\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_Meilang-headshot-copy-233x300.jpg\" class=\" wp-post-image\" alt=\"Associate Professor Meilang Xue\" srcset=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_Meilang-headshot-copy-233x300.jpg 233w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_Meilang-headshot-copy.jpg 365w\" sizes=\"auto, (max-width: 233px) 100vw, 233px\" \/>                <div class=\"team-member-content\">\n                    \n                    <h3>\n                                                    Associate Professor Meilang Xue                                            <\/h3>\n\n                    <div class=\"team-content\">\n                        \n<p class=\"is-style-text-subtitle wp-block-paragraph\" style=\"font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.156), 0.98rem);\">Sutton Arthritis Research Laboratory<br>Medicine, Northern Clinical School<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading has-accent-4-color has-text-color has-link-color wp-elements-918ab976db889b4c0e449ca011fea44f\">Team Members<\/h3>\n\n\n\n    <div class=\"team-block-page\">\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"181\" height=\"248\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_Professor-Chris-Jackson-181x248-1.jpg\" class=\" wp-post-image\" alt=\"Honorary Professor Chris Jackson\" \/>                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Honorary Professor Chris Jackson                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        \n<p class=\"wp-block-paragraph\">Retired<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Zachary O\u2019Hehir\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Zachary O\u2019Hehir                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>Research Project Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Frida Campos\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Frida Campos                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>Visiting Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Tatyana (Tanya) Fedorova\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Tatyana (Tanya) Fedorova                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>Clinical Trial Coordinator<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Hui (Vanessa) Wang\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Hui (Vanessa) Wang                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>PhD Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Siwen(Amy) Han\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Siwen(Amy) Han                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        \n<p class=\"wp-block-paragraph\">Master Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-fade\" data-selector=\"15dcc441-9734-467a-b5cc-e31f82dca9f0\" id=\"tab-1fb17064-c4f9-417c-9167-cad2cd809405\" aria-labelledby=\"1fb17064-c4f9-417c-9167-cad2cd809405\" role=\"tabpanel\">\n<div data-wp-context=\"{ &quot;autoclose&quot;: true, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-2&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-2-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-2\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><span class=\"wp-block-accordion-heading__toggle-title\">Targeting Joint Metabolism in Rheumatoid Arthritis&nbsp;<\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-2\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-2-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<ul class=\"wp-block-list\">\n<li>The Problem: In rheumatoid arthritis, abnormal immune cells and joint tissues change how they process energy. They consume excessive energy to fuel aggressive joint damage.<\/li>\n\n\n\n<li>Our Approach: We are investigating a specific cell receptor called the Endothelial protein C receptor. It acts as a master switch that may control this harmful cellular energy shift.<\/li>\n\n\n\n<li>The Impact: This research highlights a new target to stop joint damage.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: true, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-3&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-3-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-3\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><span class=\"wp-block-accordion-heading__toggle-title\">Precision Medicine in rheumatoid arthritis: Predicting Treatment Success&nbsp;<\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-3\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-3-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<ul class=\"wp-block-list\">\n<li>The Problem: Up to 40% of patients do not respond to their first biologic treatment. This trial-and-error process prolongs patient pain and costs healthcare systems millions of dollars each year.<\/li>\n\n\n\n<li>Our Approach: We combine genetic and immune data using machine learning and advanced blood screening to map individual patient profiles.<\/li>\n\n\n\n<li>The Impact: This work will create a toolkit to predict whether a treatment will work before it is prescribed.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: true, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-4&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-4-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-4\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><span class=\"wp-block-accordion-heading__toggle-title\">The Coagulation-Immunity Axis in Psoriatic Arthritis&nbsp;<\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-4\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-4-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<ul class=\"wp-block-list\">\n<li>The Problem: Many patients with psoriatic arthritis do not respond to standard treatments, leaving them with severe, ongoing joint inflammation and few alternatives.<\/li>\n\n\n\n<li>Our Approach: We are studying how specific genetic variations in a blood-clotting receptor connect blood vessel biology to immune system inflammation. We use advanced, patient-derived data models for this research.<\/li>\n\n\n\n<li>The Impact and Collaboration: By understanding how to control this inflammatory pathway, we can open new avenues for targeted treatments. We invite academic collaborators and philanthropic funders to help us scale this research and find solutions for treatment-resistant disease.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"featured_media":416,"template":"","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"primary-research-area":[56],"class_list":["post-2678","research-group","type-research-group","status-publish","has-post-thumbnail","hentry","primary-research-area-musculoskeletal"],"acf":{"team_leads":[3149],"team_members":[3378,3379,3380,3381,3382,4604]},"uagb_featured_image_src":{"full":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_Raymond-Purves.jpg",2000,590,false],"thumbnail":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_Raymond-Purves-150x150.jpg",150,150,true],"medium":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_Raymond-Purves-300x89.jpg",300,89,true],"medium_large":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_Raymond-Purves-768x227.jpg",768,227,true],"large":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_Raymond-Purves-1024x302.jpg",1024,302,true],"1536x1536":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_Raymond-Purves-1536x453.jpg",1536,453,true],"2048x2048":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_Raymond-Purves.jpg",2000,590,false]},"uagb_author_info":{"display_name":"swatee.jain@sydney.edu.au","author_link":"https:\/\/kollinginstitute.org.au\/news_demo\/author\/"},"uagb_comment_info":0,"uagb_excerpt":null,"_links":{"self":[{"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/research-group\/2678","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/research-group"}],"about":[{"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/types\/research-group"}],"version-history":[{"count":19,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/research-group\/2678\/revisions"}],"predecessor-version":[{"id":7533,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/research-group\/2678\/revisions\/7533"}],"acf:post":[{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/4604"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3382"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3381"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3380"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3379"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3378"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3149"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/media\/416"}],"wp:attachment":[{"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/media?parent=2678"}],"wp:term":[{"taxonomy":"primary-research-area","embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/primary-research-area?post=2678"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}