{"id":2674,"date":"2025-09-17T15:06:49","date_gmt":"2025-09-17T05:06:49","guid":{"rendered":"https:\/\/webdev.sydney.edu.au\/kolling\/research-group\/raymond-purves-bone-joint-research-laboratory\/"},"modified":"2026-07-11T10:06:36","modified_gmt":"2026-07-11T00:06:36","slug":"raymond-purves-bone-joint-research-laboratory","status":"publish","type":"research-group","link":"https:\/\/kollinginstitute.org.au\/news_demo\/research-group\/raymond-purves-bone-joint-research-laboratory\/","title":{"rendered":"Raymond Purves Bone &#038; Joint Research Laboratory"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-07579d57 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<div class=\"wp-block-group alignfull has-white-background-color has-background is-layout-flow wp-block-group-is-layout-flow\" style=\"padding-top:0;padding-bottom:0\">\n<div style=\"margin-top:0;margin-bottom:0;padding-top:0;padding-bottom:0;--etb-a-tab-btn-bg-color:#007ed5;--etb-a-tab-btn-text-color:#FBFAF3;--etb-a-tab-btn-heading-color:#FFFFFF;--etb-a-tab-image-filter:none;--etb-a-tab-bt-style:none;--etb-a-tab-bt-width:0px;--etb-a-tab-br-style:none;--etb-a-tab-br-width:0px;--etb-a-tab-bb-style:none;--etb-a-tab-bb-width:0px;--etb-a-tab-bl-style:none;--etb-a-tab-bl-width:0px;--etb-h-tab-btn-bg-color:color-mix(in srgb, currentColor 20%, transparent);--etb-h-tab-btn-text-color:#FBFAF3;--etb-h-tab-image-filter:none;--etb-h-tab-bb-color:#ab40a1;--etb-h-tab-bb-width:2px\" class=\"wp-block-easy-tabs-block-tabs has-active-etb-bg-color has-active-etb-text-color has-active-etb-heading-color has-active-etb-border has-active-etb-duotone has-hover-etb-bg-color has-hover-etb-text-color has-hover-etb-border  false\" data-id=\"6f4884d0-d087-4945-bf9a-2577c6ca54db\" data-initial-tab=\"1\" data-trigger=\"mouseover\" data-accessibility=\"true\"><div class=\"wp-block-easy-tabs-block-tabs-inner is-layout-flow wp-block-easy-tabs-block-tabs-is-layout-flow\">\n<div class=\"etb-tabs-buttons-scrollable-with-arrows wp-container-content-9cfa9a5a\"><div class=\"wp-block-easy-tabs-block-tab-buttons has-etb-buttons-scrollable has-small-font-size is-content-justification-left is-layout-flex wp-container-easy-tabs-block-tab-buttons-is-layout-1a549490 wp-block-easy-tabs-block-tab-buttons-is-layout-flex\" style=\"border-bottom-color:var(--wp--preset--color--accent-6);border-bottom-width:1px;padding-top:0;padding-bottom:0\" data-selector=\"6f4884d0-d087-4945-bf9a-2577c6ca54db\" role=\"tablist\">\n<button class=\"wp-block-easy-tabs-block-tab-button has-text-color has-link-color wp-elements-d915b7e27ed797cc7d89252f9646bc75\" style=\"color:#101827\" data-selector=\"6f4884d0-d087-4945-bf9a-2577c6ca54db\" id=\"9ea9395a-fec0-4f95-9b27-750fbe4183de\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab-9ea9395a-fec0-4f95-9b27-750fbe4183de\" tabindex=\"-1\">\n<h2 class=\"wp-block-heading has-contrast-color has-text-color has-link-color has-medium-font-size wp-elements-ff56fb5b180573e3245b4ec13836c990\" style=\"margin-top:0;margin-bottom:0;padding-top:0;padding-bottom:0\">About us<\/h2>\n<\/button>\n\n\n\n<button class=\"wp-block-easy-tabs-block-tab-button has-contrast-color has-text-color has-link-color wp-elements-fb11a822aa4768ef779fbb31d624430f\" style=\"font-size:clamp(14px, 0.875rem + ((1vw - 3.2px) * 0.185), 16px);font-style:normal;font-weight:600;line-height:1.5\" data-selector=\"6f4884d0-d087-4945-bf9a-2577c6ca54db\" id=\"ae817739-7f70-4dc8-963c-560c7e62418d\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab-ae817739-7f70-4dc8-963c-560c7e62418d\" tabindex=\"-1\">\n<h2 class=\"wp-block-heading has-medium-font-size\">Our Team<\/h2>\n<\/button>\n\n\n\n<button class=\"wp-block-easy-tabs-block-tab-button has-contrast-color has-text-color has-link-color wp-elements-cf35617ca6fc00247f9abe8d3c0752cf\" style=\"font-size:clamp(14px, 0.875rem + ((1vw - 3.2px) * 0.185), 16px);font-style:normal;font-weight:600;line-height:1.5\" data-selector=\"6f4884d0-d087-4945-bf9a-2577c6ca54db\" id=\"e34844b6-6653-4eb0-b5fb-0e59b37ef209\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab-e34844b6-6653-4eb0-b5fb-0e59b37ef209\" tabindex=\"-1\">\n<h2 class=\"wp-block-heading has-medium-font-size\">Projects<\/h2>\n<\/button>\n\n\n\n<button class=\"wp-block-easy-tabs-block-tab-button has-text-color has-link-color wp-elements-6b5881547892f808764c3e7dd3d4749f\" style=\"color:#101827\" data-selector=\"6f4884d0-d087-4945-bf9a-2577c6ca54db\" id=\"13768534-279f-4ffd-921d-f88c7d1ad102\" role=\"tab\" aria-selected=\"false\" aria-controls=\"tab-13768534-279f-4ffd-921d-f88c7d1ad102\" tabindex=\"-1\">\n<h2 class=\"wp-block-heading has-contrast-color has-text-color has-link-color has-medium-font-size wp-elements-fc8e63bdef8ffff0f650df89bd2e5a68\">Collaborations<\/h2>\n<\/button>\n<\/div><button class=\"etb-scroll-button left\" aria-label=\"Scroll to the left\"><span class=\"chevron-left\"><\/span><\/button><button class=\"etb-scroll-button right\" aria-label=\"Scroll to the right\"><span class=\"chevron-right\"><\/span><\/button><\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-contents\" style=\"border-style:none;border-width:0px\">\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-fade\" data-selector=\"6f4884d0-d087-4945-bf9a-2577c6ca54db\" id=\"tab-9ea9395a-fec0-4f95-9b27-750fbe4183de\" aria-labelledby=\"9ea9395a-fec0-4f95-9b27-750fbe4183de\" role=\"tabpanel\">\n<p class=\"wp-block-paragraph\">The University of Sydney Raymond Purves Bone and Joint Research Laboratory, leads Australia in research into some of the key musculoskeletal diseases affecting our population. This includes osteoarthritis, tendon and ligament injury and intervertebral disc degeneration.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There is currently no cure for these common, chronic disabling conditions and long-term management options are limited. It is only through a better understanding of the cellular and molecular mechanisms of disease, tissue breakdown and associated pain, that we will be able to develop effective preventions and treatments.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Working in close collaboration with orthopaedic surgeons and rheumatologists at Royal North Shore Hospital, and national and international industry partners, our latest research developments can be efficiently incorporated into future clinical care, to improve the health of patients with musculoskeletal disease.&nbsp;&nbsp;<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-fade\" style=\"padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\" data-selector=\"6f4884d0-d087-4945-bf9a-2577c6ca54db\" id=\"tab-ae817739-7f70-4dc8-963c-560c7e62418d\" aria-labelledby=\"ae817739-7f70-4dc8-963c-560c7e62418d\" role=\"tabpanel\">\n<div class=\"wp-block-group has-background has-global-padding is-layout-constrained wp-container-core-group-is-layout-fb7be5c4 wp-block-group-is-layout-constrained\" style=\"background-color:#0000000d;margin-top:var(--wp--preset--spacing--70);margin-bottom:var(--wp--preset--spacing--70);padding-top:var(--wp--preset--spacing--50);padding-right:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50);padding-left:var(--wp--preset--spacing--50)\">\n<h3 class=\"wp-block-heading has-contrast-color has-text-color has-link-color wp-elements-0df2b60564b8e462012545eec83a1e36\">Team Lead<\/h3>\n\n\n    <div class=\"team-block-page is-single-lead\">\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/10\/images-2-1-300x300.jpg\" class=\" wp-post-image\" alt=\"\" srcset=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/10\/images-2-1-300x300.jpg 300w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/10\/images-2-1-150x150.jpg 150w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/10\/images-2-1-768x768.jpg 768w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/10\/images-2-1.jpg 1000w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>                <div class=\"team-member-content\">\n                    \n                    <h3>\n                                                    Professor Chris Little                                            <\/h3>\n\n                    <div class=\"team-content\">\n                        \n<p class=\"is-style-text-subtitle wp-block-paragraph\" style=\"font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.156), 0.98rem);\">Director Raymond Purves Bone and Joint Research Lab<br>Surgery, Faculty of Medicine and Health, Northern Clinical School<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading has-accent-4-color has-text-color has-link-color wp-elements-918ab976db889b4c0e449ca011fea44f\">Team Members<\/h3>\n\n\n\n    <div class=\"team-block-page\">\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"181\" height=\"233\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_Dr-Jiao-Jiao-Li-181x233-1.jpg\" class=\" wp-post-image\" alt=\"Dr Jiao Jiao Li\" \/>                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Dr Jiao Jiao Li                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        \n<p class=\"wp-block-paragraph\">Honorary Associate<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"181\" height=\"232\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_Dr-Cindy-Shu-181x232-1.jpg\" class=\" wp-post-image\" alt=\"Dr Cindy Shu\" \/>                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Dr Cindy Shu                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        \n<p class=\"wp-block-paragraph\">Research Fellow<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"180\" height=\"270\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_team-Dr-Sanaa-Zaki.jpg\" class=\" wp-post-image\" alt=\"Associate Professor Sanaa Zaki\u00a0\" \/>                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Associate Professor Sanaa Zaki\u00a0                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        \n<p class=\"is-style-text-subtitle wp-block-paragraph\" style=\"font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.156), 0.98rem);\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-accent-3-color\"><strong>Co-Chair, Neuroscience and Pain<\/strong><\/mark><\/p>\n\n\n\n<p class=\"is-style-text-subtitle wp-block-paragraph\" style=\"font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.156), 0.98rem);\">Postdoctoral Scientist <br>Raymond Purves Bone and Joint Research<\/p>\n\n\n\n<p class=\"is-style-text-subtitle wp-block-paragraph\" style=\"font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.156), 0.98rem);\"><br><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Dr James Melrose\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Dr James Melrose                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>Honorary Senior Research Fellow<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Daniel Burkhardt\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Daniel Burkhardt                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>Research Officer<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Susan Smith\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Susan Smith                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>Technical Officer<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Jiarong (Devina) Li \u2013 PhD Student\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Jiarong (Devina) Li \u2013 PhD Student                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                                            <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Harrison Johansen\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Harrison Johansen                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>Honours Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Kate Hoare\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Kate Hoare                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>Honours Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Sidharth Aravind\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Sidharth Aravind                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>PhD Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Ye (Janey) Zhang\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Ye (Janey) Zhang                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>Visiting Researcher<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Roshana Vander Wall\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Roshana Vander Wall                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>Research Assistant<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Jiaqi (Yancy) Chen\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Jiaqi (Yancy) Chen                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>Honours Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Zhiyu Mu\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Zhiyu Mu                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>Masters Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Sofia Drakoulis\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Sofia Drakoulis                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>Honours Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Thai Khang (Ken) Hy\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Thai Khang (Ken) Hy                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        <p>PhD Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Renee Nayager\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Renee Nayager                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        \n<p class=\"wp-block-paragraph\">Research Student<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img decoding=\"async\" src=\"https:\/\/kollinginstitute.org.au\/wp-content\/uploads\/2025\/10\/headshot_placeholder.png\" class=\"attachment-medium size-medium\" alt=\"Jasmine Faddis\">                <div class=\"team-member-content\">\n                                        \n                    <h3>\n                                                    Jasmine Faddis                                            <\/h3>\n                    \n                    <div class=\"team-content\">\n                        \n<p class=\"wp-block-paragraph\">Honours Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-fade\" data-selector=\"6f4884d0-d087-4945-bf9a-2577c6ca54db\" id=\"tab-e34844b6-6653-4eb0-b5fb-0e59b37ef209\" aria-labelledby=\"e34844b6-6653-4eb0-b5fb-0e59b37ef209\" role=\"tabpanel\">\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-2&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-2-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-2\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><span class=\"wp-block-accordion-heading__toggle-title\">Bad knees and broken hearts: defining how osteoarthritis (OA) increases the risk of cardiovascular disease (CVD). <\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-2\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-2-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<p class=\"wp-block-paragraph\">It has long been known that individuals with OA have a nearly 2-fold greater risk of CVD. This connection has been associated with shared risk factors (ageing, obesity) and OA, reducing physical activity. Our novel research, funded by an NHMRC Ideas Grant (2024-26) and the Hillcrest Foundation through Perpetual Philanthropies (2021-22 &amp; 26-28), is defining a new pathway where molecules released from injured and diseased OA joint tissues enter the blood and directly damage heart cells. <strong><em>Identifying these factors and defining how they injure and affect heart cells, will open new avenues to diagnose and manage CVD risk.<\/em><\/strong>&nbsp;&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-3&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-3-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-3\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><span class=\"wp-block-accordion-heading__toggle-title\">Mild joint injury &#8211; the hidden driver of increasing risk of anterior cruciate ligament (ACL) rupture and subsequent post-traumatic osteoarthritis (OA). <\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-3\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-3-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Despite active injury prevention programs Australia leads the world in rising rates of ACL ruptures. Our research has revealed that this increasing burden reflects two key limiting factors: unresolved biological ris<strong>k <\/strong>whereby prior mild\/non-rupture knee injuries cause a progressive remodelling of the ACL, silently eroding tissue strength until failure occurs during normal activity;absence of widely accessible prognostic toolsto identify individuals with silent, load-induced ACL weakening and elevated rupture risk who would benefit from targeted injury-prevention efforts. In studies funded by the Hillcrest Foundation (2023-25), Arthritis Australia (2024) and Sydney Musculoskeletal Health (2026), we are defining the sex-specific biological tissue changes driving load-induced ACL weakening. We aim to translate mechanistic insights into real-world solutions by defining blood-based biomarkers to identify individuals whose ACLs are on a trajectory toward rupture; and with colleagues in Melbourne develop enhanced quantitative measures of ACL loads in people to enable detection of injury-inducing events.<strong><em> This work will critically advance ACL injury prevention by enabling the right individuals to be targeted at the right time.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-4&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-4-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-4\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><span class=\"wp-block-accordion-heading__toggle-title\">New strategies to prevent long-term disease following knee joint injury. <\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-4\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-4-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Progressive joint breakdown and chronic pain following joint injury is known as post-traumatic osteoarthritis (ptOA). Current treatments including surgery and bracing can restore joint biomechanics and return individuals to activity, but they fail to prevent long-term consequences with ~50% of individuals developing ptOA within 15 years irrespective of intervention. Our research funded by NHMRC (2013-17), Arthritis Australia (2015) and the Hillcrest Foundation (2019-20 &amp; 22-23), has identified specific inflammatory and immune cell responses that occur in the joint acutely after ptOA-inducing but not non-OA-inducing knee injuries. Critically, inhibiting these immune cell changes just in the immediate 3-5 day peri-injury period modifies long-term joint inflammation and most importantly ptOA joint pathology. We are now defining the optimal therapeutic agent(s) and treatment window for joint immune reprogramming by repurposing already available immune-therapeutics to enable rapid clinical implementation. Targeting the rising prevalence of knee ptOA in a younger active population is a critical research priority to prevent lifelong disability. <strong><em>Our research program will shift clinical practice from ptOA management towards ptOA prevention.<\/em><\/strong>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-fade\" data-selector=\"6f4884d0-d087-4945-bf9a-2577c6ca54db\" id=\"tab-13768534-279f-4ffd-921d-f88c7d1ad102\" aria-labelledby=\"13768534-279f-4ffd-921d-f88c7d1ad102\" role=\"tabpanel\">\n<ul class=\"wp-block-list\">\n<li>Professor Anthony Ashton, Lankenau Institute for Medical Research, Pennsylvania; discovery research academic partnership Professor Adam Bryant and Dr Scott Starkey, University of Melbourne; discovery research academic partnership<\/li>\n\n\n\n<li>Professor Farshid Guilak, Washington University, St Louis Missouri; discovery research academic partnership<\/li>\n\n\n\n<li>Professor Paul Hodges, University of Queensland; discovery research academic partnership<\/li>\n\n\n\n<li>Dr Sohel Julovi and Professor Natasha Rogers, Westmead Institute of Medical Research; discovery research academic partnership.<\/li>\n\n\n\n<li>Professor Mohit Kapoor, University of Toronto &amp; Schroeder Arthritis Institute, University Health Network; discovery research academic partnership<\/li>\n\n\n\n<li>Professor Shireen Lamande, Murdoch Children\u2019s Research Institute; discovery research academic partnership<\/li>\n\n\n\n<li>Dr Anastasia Mihailidou, Cardiovascular &amp; Hormonal Research Laboratory Department of Cardiology, Royal North Shore Hospital; discovery research academic partnership<\/li>\n\n\n\n<li>Professor Babak Moradi, Orthopedic Research Center, Kiel University; discovery research academic partnership<\/li>\n\n\n\n<li>Professor Carla Scanzello, University of Pennsylvania, Institute for Immunology &amp; Immune Health, Perelman School of Medicine; discovery research academic partnership<\/li>\n\n\n\n<li>Professor Aaron Schindler, The Children\u2019s Hospital Westmead; discovery research academic partnership<\/li>\n\n\n\n<li>Fidia Farmaceutici S.p.A., Abano Terme, Italy; industry collaboraation &amp; engagement<\/li>\n\n\n\n<li>Interpath Pty Ltd, Ballarat, Victoria; industry collaboration &amp; engagement<\/li>\n\n\n\n<li>Taiwan Liposome Company Ltd., Taipei, Taiwan, industry engagement<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"featured_media":416,"template":"","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-2674","research-group","type-research-group","status-publish","has-post-thumbnail","hentry"],"acf":{"team_leads":[3152],"team_members":[3258,3259,3163,3261,3262,3263,3264,3265,3266,3267,3268,3269,3270,3271,3272,3273,4865,5092]},"uagb_featured_image_src":{"full":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_Raymond-Purves.jpg",2000,590,false],"thumbnail":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_Raymond-Purves-150x150.jpg",150,150,true],"medium":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_Raymond-Purves-300x89.jpg",300,89,true],"medium_large":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_Raymond-Purves-768x227.jpg",768,227,true],"large":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_Raymond-Purves-1024x302.jpg",1024,302,true],"1536x1536":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_Raymond-Purves-1536x453.jpg",1536,453,true],"2048x2048":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_Raymond-Purves.jpg",2000,590,false]},"uagb_author_info":{"display_name":"ict-wordpress-support@sydney.edu.au","author_link":"https:\/\/kollinginstitute.org.au\/news_demo\/author\/"},"uagb_comment_info":0,"uagb_excerpt":null,"_links":{"self":[{"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/research-group\/2674","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/research-group"}],"about":[{"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/types\/research-group"}],"version-history":[{"count":14,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/research-group\/2674\/revisions"}],"predecessor-version":[{"id":6746,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/research-group\/2674\/revisions\/6746"}],"acf:post":[{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/5092"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/4865"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3273"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3272"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3271"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3270"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3269"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3268"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3267"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3266"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3265"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3264"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3263"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3262"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3261"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3163"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3259"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3258"},{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/team-members\/3152"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/media\/416"}],"wp:attachment":[{"href":"https:\/\/kollinginstitute.org.au\/news_demo\/wp-json\/wp\/v2\/media?parent=2674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}