{"id":2662,"date":"2025-09-17T15:06:45","date_gmt":"2025-09-17T05:06:45","guid":{"rendered":"https:\/\/webdev.sydney.edu.au\/kolling\/research-group\/haematology\/"},"modified":"2026-02-19T10:10:48","modified_gmt":"2026-02-18T23:10:48","slug":"haematology","status":"publish","type":"research-group","link":"https:\/\/kollinginstitute.org.au\/news_demo\/research-group\/haematology\/","title":{"rendered":"Haematology"},"content":{"rendered":"\n<p>The Northern Blood Research Centre is the research division of Royal North Shore Hospital\u2019s Department of Haematology and Transfusion Medicine.<\/p>\n\n\n\n<p>Our projects focus on improving patient care through a better understanding of clinical disorders. We run trials of new anti-cancer agents and immunotherapy to overcome drug resistance. We also examine cellular systems to model disease states.<\/p>\n\n\n\n<p>Our group of clinicians, scientists and nurses run research programs in thrombosis and haemostasis, lymphoproliferative disorders, stem cell biology and transplant outcomes.<\/p>\n\n\n\n<p>Our laboratory is an international reference centre for platelet disorders, and provides training for young clinicians and scientists establishing careers in haematology.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Eosinophilic leukaemia in a patient<\/h4>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"824\" height=\"720\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/root_Content_Eosinophilic-leukaemia-in-a-patient-wth-mutatin-of-the-RUNX1-transcription-factor.jpg\" alt=\"Eosinophilic leukaemia in a patient\n\" class=\"wp-image-2963\" srcset=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/root_Content_Eosinophilic-leukaemia-in-a-patient-wth-mutatin-of-the-RUNX1-transcription-factor.jpg 824w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/root_Content_Eosinophilic-leukaemia-in-a-patient-wth-mutatin-of-the-RUNX1-transcription-factor-300x262.jpg 300w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/root_Content_Eosinophilic-leukaemia-in-a-patient-wth-mutatin-of-the-RUNX1-transcription-factor-768x671.jpg 768w\" sizes=\"auto, (max-width: 824px) 100vw, 824px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">Structure of the P2Y12 receptor<\/h4>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"652\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/root_Content_Structure-of-the-P2Y12-receptor.jpg\" alt=\"Eosinophilic leukaemia in a patient\n\" class=\"wp-image-2964\" srcset=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/root_Content_Structure-of-the-P2Y12-receptor.jpg 750w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/root_Content_Structure-of-the-P2Y12-receptor-300x261.jpg 300w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/><\/figure>\n\n\n\n<div style=\"border-style:none;border-width:0px;--etb-a-tab-btn-bg-color:#FFFFFF;--etb-a-tab-btn-text-color:#ab40a1;--etb-a-tab-btn-heading-color:#ffffff;--etb-a-tab-bt-style:none;--etb-a-tab-bt-width:0px;--etb-a-tab-br-style:none;--etb-a-tab-br-width:0px;--etb-a-tab-bb-style:none;--etb-a-tab-bb-width:0px;--etb-a-tab-bl-style:none;--etb-a-tab-bl-width:0px;--etb-h-tab-btn-bg-color:#ffffff;--etb-h-tab-btn-text-color:#000000;--etb-h-tab-btn-heading-color:#000000;--etb-h-tab-bt-style:none;--etb-h-tab-bt-width:0px;--etb-h-tab-br-style:none;--etb-h-tab-br-width:0px;--etb-h-tab-bb-style:none;--etb-h-tab-bb-width:0px;--etb-h-tab-bl-style:none;--etb-h-tab-bl-width:0px;--etb-scroll-arrows-icon-color:#ab40a1\" class=\"wp-block-easy-tabs-block-tabs has-active-etb-bg-color has-active-etb-text-color has-active-etb-heading-color has-active-etb-border has-hover-etb-bg-color has-hover-etb-text-color has-hover-etb-heading-color has-hover-etb-border\" data-id=\"fe03d8d4-8613-4cb2-99d4-227f54cd784c\" data-initial-tab=\"1\" data-trigger=\"click\"><div class=\"wp-block-easy-tabs-block-tabs-inner is-layout-flow wp-block-easy-tabs-block-tabs-is-layout-flow\">\n<div class=\"etb-tabs-buttons-scrollable-with-arrows\"><div class=\"wp-block-easy-tabs-block-tab-buttons has-etb-buttons-scrollable is-layout-flex wp-container-easy-tabs-block-tab-buttons-is-layout-d7af6e26 wp-block-easy-tabs-block-tab-buttons-is-layout-flex\" style=\"border-style:none;border-width:0px\" data-selector=\"fe03d8d4-8613-4cb2-99d4-227f54cd784c\">\n<div class=\"wp-block-easy-tabs-block-tab-button\" style=\"border-style:none;border-width:0px\" data-selector=\"fe03d8d4-8613-4cb2-99d4-227f54cd784c\">\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"43\" height=\"39\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Icons_lead-icon2.png\" alt=\"\" class=\"wp-image-1098\" style=\"width:20px\"\/><\/figure>\n\n\n\n<p style=\"border-style:none;border-width:0px;padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--20);padding-bottom:0;padding-left:var(--wp--preset--spacing--20)\">Lead<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-button\" style=\"border-style:none;border-width:0px\" data-selector=\"fe03d8d4-8613-4cb2-99d4-227f54cd784c\">\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"43\" height=\"39\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Icons_people-icon2.png\" alt=\"\" class=\"wp-image-1114\" style=\"width:20px\"\/><\/figure>\n\n\n\n<p style=\"border-style:none;border-width:0px;padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--20);padding-bottom:0;padding-left:var(--wp--preset--spacing--20)\">People<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-button\" style=\"border-style:none;border-width:0px\" data-selector=\"fe03d8d4-8613-4cb2-99d4-227f54cd784c\">\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"43\" height=\"39\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Icons_network-icon2.png\" alt=\"\" class=\"wp-image-1103\" style=\"width:20px\"\/><\/figure>\n\n\n\n<p style=\"border-style:none;border-width:0px;padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--20);padding-bottom:0;padding-left:var(--wp--preset--spacing--20)\">Network<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-button\" style=\"border-style:none;border-width:0px\" data-selector=\"fe03d8d4-8613-4cb2-99d4-227f54cd784c\">\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"43\" height=\"39\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Icons_projects-icon2.png\" alt=\"\" class=\"wp-image-1120\" style=\"width:20px\"\/><\/figure>\n\n\n\n<p style=\"padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--20);padding-bottom:0;padding-left:var(--wp--preset--spacing--20)\">Projects<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-button\" style=\"border-style:none;border-width:0px\" data-selector=\"fe03d8d4-8613-4cb2-99d4-227f54cd784c\">\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"43\" height=\"39\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/root_Icons_publications-icon2.png\" alt=\"\" class=\"wp-image-2818\" style=\"width:20px\"\/><\/figure>\n\n\n\n<p style=\"padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--20);padding-bottom:0;padding-left:var(--wp--preset--spacing--20)\">Publications<\/p>\n<\/div>\n<\/div>\n<\/div><button class=\"etb-scroll-button left\" aria-label=\"Scroll to the left\"><span class=\"chevron-left\"><\/span><\/button><button class=\"etb-scroll-button right\" aria-label=\"Scroll to the right\"><span class=\"chevron-right\"><\/span><\/button><\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-contents has-border-color has-accent-6-border-color\" style=\"border-width:1px\">\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-slide-up\" data-selector=\"fe03d8d4-8613-4cb2-99d4-227f54cd784c\">    <div class=\"team-block-page\">\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"180\" height=\"270\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_Professor-Christopher-Ward.jpg\" class=\" wp-post-image\" alt=\"Professor Christopher Ward\" \/>                <div class=\"team-member-content\">\n                    <h3>Professor Christopher Ward<\/h3>\n                    <div class=\"team-content\">\n                        \n<p class=\"is-style-text-subtitle\" style=\"font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.191), 0.98rem);\">Northern Blood Research<br>Senior Staff Specialist and Director of Research<br>Department of Haematology, RNSH<br>Medicine, Northern Clinical School<br><\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-slide-up\" data-selector=\"fe03d8d4-8613-4cb2-99d4-227f54cd784c\">    <div class=\"team-block-page\">\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"181\" height=\"234\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_Dr-Chris-Weir-181x234-1.jpg\" class=\" wp-post-image\" alt=\"Dr Chris Weir\" \/>                <div class=\"team-member-content\">\n                    <h3>Dr Chris Weir<\/h3>\n                    <div class=\"team-content\">\n                        \n<p>Postdoctoral Scientist<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"180\" height=\"270\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_Dr-Marie-Christine-Morel-Kopp.jpg\" class=\" wp-post-image\" alt=\"Dr Marie-Christine Morel-Kopp\" \/>                <div class=\"team-member-content\">\n                    <h3>Dr Marie-Christine Morel-Kopp<\/h3>\n                    <div class=\"team-content\">\n                        \n<p>Postdoctoral Scientist<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"181\" height=\"240\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_Professor-William-Stevenson-181x240-1.jpg\" class=\" wp-post-image\" alt=\"Clinical Professor William Stevenson\" \/>                <div class=\"team-member-content\">\n                    <h3>Clinical Professor William Stevenson<\/h3>\n                    <div class=\"team-content\">\n                        \n<p>Clinical Associate Professor<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"181\" height=\"236\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_Dr-Stephen-Mulligan-181x236-1.jpg\" class=\" wp-post-image\" alt=\"Professor Stephen Mulligan\" \/>                <div class=\"team-member-content\">\n                    <h3>Professor Stephen Mulligan<\/h3>\n                    <div class=\"team-content\">\n                        \n<p>Senior Staff Specialist, Royal North Shore Hospital<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Professor Ian Kerridge<\/h3>\n                    <div class=\"team-content\">\n                        <p>Senior Staff Specialist, Royal North Shore Hospital<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Dr David Rabbolini (Affiliate)<\/h3>\n                    <div class=\"team-content\">\n                        <p>Clinical Senior Lecturer<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"181\" height=\"220\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_Dr-Grace-Gifford.png\" class=\" wp-post-image\" alt=\"Dr Grace Gifford\" \/>                <div class=\"team-member-content\">\n                    <h3>Dr Grace Gifford<\/h3>\n                    <div class=\"team-content\">\n                        \n<p>Hospital Scientist<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"181\" height=\"272\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_Dr-Wei-Xia.jpg\" class=\" wp-post-image\" alt=\"Dr Wei Xia\" \/>                <div class=\"team-member-content\">\n                    <h3>Dr Wei Xia<\/h3>\n                    <div class=\"team-content\">\n                        \n<p>Hospital scientist<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Dr Li Jun Bai<\/h3>\n                    <div class=\"team-content\">\n                        <p>Hospital scientist<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Dr Matt Greenwood<\/h3>\n                    <div class=\"team-content\">\n                        <p>Hospital Scientist<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Walter Chen<\/h3>\n                    <div class=\"team-content\">\n                        <p>Research Assistant<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Eva Yip<\/h3>\n                    <div class=\"team-content\">\n                        <p>Clinical  Trials Nurse<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Thomas Hunenburg<\/h3>\n                    <div class=\"team-content\">\n                        <p>Masters Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Yandong (Peter) Shen<\/h3>\n                    <div class=\"team-content\">\n                        <p>Research Fellow<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Ahmad Alcheikh<\/h3>\n                    <div class=\"team-content\">\n                                            <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>George Mason<\/h3>\n                    <div class=\"team-content\">\n                        <p>Clinical Associate Lecturer<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Shane Kirk<\/h3>\n                    <div class=\"team-content\">\n                        <p>Project Officer<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Ameya Hanamshet<\/h3>\n                    <div class=\"team-content\">\n                        <p>Molecular Haematology Fellow<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Helen Impey<\/h3>\n                    <div class=\"team-content\">\n                        <p>Quality Officer<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Tsun (Carol) Tse<\/h3>\n                    <div class=\"team-content\">\n                        \n<p>Registered Nurse<\/p>\n\n\n\n<p><\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-slide-up\" data-selector=\"fe03d8d4-8613-4cb2-99d4-227f54cd784c\">\n<p>The Department of Haematology and Transfusion Medicine is linked to the Northern Sydney Cancer Network. It provides patient care including stem cell transplants.<\/p>\n\n\n\n<p>The Northern Blood Research Centre has joined with three other teaching hospitals in NSW to form the Sydney Platelet Group, providing an integrated diagnostic pathway for inherited platelet disorders.<\/p>\n\n\n\n<p>Our laboratory performs targeted gene sequencing and protein analyses, run by Dr Marie-Christine Morel-Kopp. The Northern Blood Research Centre also provides platelet genotyping for referring clinicians throughout Australia, New Zealand and Southeast Asia.<\/p>\n\n\n\n<p>Leukaemia and lymphoma studies at the Northern Blood Research Centre, led by Professors Stephen Mulligan and William Stevenson focus on the development of new therapeutics, as part of the Chronic Lymphocytic Leukemia Australian Research Consortium.<\/p>\n\n\n\n<p>The Cancer Vaccine programme led by Dr Chris Weir involves collaborations with the University of Sydney Veterinary School, Flinders University, Vaxine, University of Queensland Veterinary School and veterinary hospitals throughout Australia.<\/p>\n\n\n\n<p>Clinical trials conducted by the Department of Haematology and Transfusion Medicine include international and national multicentre trials via the Australian Leukaemia and Lymphoma Study Group and Australian Myeloma Research Consortium.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-slide-up\" data-selector=\"fe03d8d4-8613-4cb2-99d4-227f54cd784c\">\n<p>Molecular diagnosis of inherited platelet disorders \u2013 genotyping and laboratory validation of suspected pathogenic variants<\/p>\n\n\n\n<p>Targeted therapy of lymphoproliferative disorders (CLL and lymphoma) \u2013 biological risk factors and screening of new therapeutics<\/p>\n\n\n\n<p>Cancer vaccines in veterinary medicine \u2013 leading to early phase clinical trials in human patients<\/p>\n\n\n\n<p>Stem cell biology in transplant medicine, long-term outcomes in transplant survivors<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-slide-up\" data-selector=\"fe03d8d4-8613-4cb2-99d4-227f54cd784c\">\n<p>Nguyen TN, Morel-Kopp MC, Pepperell D, Cumming RG, Hilmer SN, Ward CM: The impact of frailty on coagulation and responses to warfarin in acute older hospitalised patients with atrial fibrillation: a pilot study. Aging Clin Exp Res 2017 Mar 2. doi: 10.1007\/s40520-017-0733-8.<\/p>\n\n\n\n<p>DJ Rabbolini, Y Chun, M Latimer, S Kunishima, K Fixter, B Valecha, P Tan, LP Chew, BT Kile, R Burt, K Radhakrishnan, R Bird, P Ockelford, S Gabrielli, Q Chen, WS. Stevenson , CM. Ward and M-C Morel-Kopp: Diagnosis and treatment of MYH9-RD in an Australasian cohort with thrombocytopenia, Platelets. 2017 Nov 1:1-8. doi: 10.1080\/09537104.2017.1356920.<\/p>\n\n\n\n<p>D. J. Rabbolini, M-C. Morel-Kopp, Q. Chen, S. Gabrielli, L. Dunlop, T. Brighton, C. M. Ward and W. S. Stevenson: Thrombocytopenia and CD34 expression is decoupled from \u00ce\u00b1-granule deficiency with mutation of the first GFI1B zinc finger. J Thromb Haemost. 2017 15(11):2245-2258. doi: 10.1111\/jth.13843.<\/p>\n\n\n\n<p>SJ Mundell, DJ Rabbolini, S Gabrielli, Q Chen, R Aungraheeta, T Kilo, J Mackay, CM Ward, WS Stevenson and M-C Morel-Kopp: Receptor homodimerization plays a critical role in a novel dominant negative P2RY12 variant identified in a family with severe bleeding. J Thromb Haemost. 2018 16(1):44-53. doi: 10.1111\/jth.13900.<\/p>\n\n\n\n<p>Shen Y, Crassini K, Sandhu S, et al. . Dual inhibition of MEK1\/2 and AKT by binimetinib and MK2206 induces apoptosis of chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment. Leuk Lymphoma 2019 ;60:1632-1643.<\/p>\n\n\n\n<p>Shen Y, Best OG, Mulligan SP, Christopherson RI. Ibrutinib and idelalisib block immunophenotypic changes associated with the adhesion and activation of CLL cells in the tumor microenvironment. Leuk Lymphoma 2018;59:1927-1937.<\/p>\n\n\n\n<p>Weir CJ Oska et al (2018) The safety of an adjuvanted autologous cancer vaccine platform in canine cancer patients.&nbsp;<a rel=\"noreferrer noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=The+safety+of+an+adjuvanted+autologous+cancer+vaccine+platform+in+canine+cancer+patients\" target=\"_blank\">Vet Sci<\/a>. 2018 5(4) pii: E87. doi: 10.3390\/vetsci5040087.<\/p>\n\n\n\n<p>Joanne Joseph, David Rabbolini, Anoop K Enjeti, Emmanuel Favaloro, Marie-Christine Kopp, Simon McRae, Leonardo Pasalic, Tan Chee Wee, Christopher M Ward, Beng H Chong: Diagnosis and management of heparin induced thrombocytopenia: a consensus statement document from THANZ HIT Writing Group. 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