{"id":2656,"date":"2025-09-17T15:06:45","date_gmt":"2025-09-17T05:06:45","guid":{"rendered":"https:\/\/webdev.sydney.edu.au\/kolling\/research-group\/cardiovascular-discovery-group\/"},"modified":"2026-02-19T10:08:43","modified_gmt":"2026-02-18T23:08:43","slug":"cardiovascular-discovery-group","status":"publish","type":"research-group","link":"https:\/\/kollinginstitute.org.au\/news_demo\/research-group\/cardiovascular-discovery-group\/","title":{"rendered":"Cardiovascular Discovery Group"},"content":{"rendered":"\n<p>The Cardiovascular Discovery Group focuses on identifying new ways to treat cardiovascular disease. The key aim of our research is to improve the survival and wellbeing of people with heart disease and those who are susceptible to developing the disease. We do this through a research program of translational and clinical research.<\/p>\n\n\n\n<p>Our team works across the leading academic hospital, Royal North Shore Hospital and the Kolling Institute. This means we are in a good position to transfer our research outcomes to clinical practice. It also means our clinical experience directly informs our research programs. Our current research involves translational basic science, clinical trials and patient studies.<\/p>\n\n\n\n<p>It is focusing on the following areas:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Redox signaling<\/li>\n\n\n\n<li>Inflammation therapies<\/li>\n\n\n\n<li>Biomarker discovery<\/li>\n\n\n\n<li>Vascular dysfunction<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"548\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/root_Content_Figtree-Team.jpg\" alt=\"\" class=\"wp-image-2926\" srcset=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/root_Content_Figtree-Team.jpg 1000w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/root_Content_Figtree-Team-300x164.jpg 300w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/root_Content_Figtree-Team-768x421.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<div style=\"border-style:none;border-width:0px;--etb-a-tab-btn-bg-color:#FFFFFF;--etb-a-tab-btn-text-color:#ab40a1;--etb-a-tab-btn-heading-color:#ffffff;--etb-a-tab-bt-style:none;--etb-a-tab-bt-width:0px;--etb-a-tab-br-style:none;--etb-a-tab-br-width:0px;--etb-a-tab-bb-style:none;--etb-a-tab-bb-width:0px;--etb-a-tab-bl-style:none;--etb-a-tab-bl-width:0px;--etb-h-tab-btn-bg-color:#ffffff;--etb-h-tab-btn-text-color:#000000;--etb-h-tab-btn-heading-color:#000000;--etb-h-tab-bt-style:none;--etb-h-tab-bt-width:0px;--etb-h-tab-br-style:none;--etb-h-tab-br-width:0px;--etb-h-tab-bb-style:none;--etb-h-tab-bb-width:0px;--etb-h-tab-bl-style:none;--etb-h-tab-bl-width:0px;--etb-scroll-arrows-icon-color:#ab40a1\" class=\"wp-block-easy-tabs-block-tabs has-active-etb-bg-color has-active-etb-text-color has-active-etb-heading-color has-active-etb-border has-hover-etb-bg-color has-hover-etb-text-color has-hover-etb-heading-color has-hover-etb-border\" data-id=\"b528f1b7-7123-414d-884f-478054a3abb0\" data-initial-tab=\"1\" data-trigger=\"click\"><div class=\"wp-block-easy-tabs-block-tabs-inner is-layout-flow wp-block-easy-tabs-block-tabs-is-layout-flow\">\n<div class=\"etb-tabs-buttons-scrollable-with-arrows\"><div class=\"wp-block-easy-tabs-block-tab-buttons has-etb-buttons-scrollable is-layout-flex wp-container-easy-tabs-block-tab-buttons-is-layout-d7af6e26 wp-block-easy-tabs-block-tab-buttons-is-layout-flex\" style=\"border-style:none;border-width:0px\" data-selector=\"b528f1b7-7123-414d-884f-478054a3abb0\">\n<div class=\"wp-block-easy-tabs-block-tab-button\" style=\"border-style:none;border-width:0px\" data-selector=\"b528f1b7-7123-414d-884f-478054a3abb0\">\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"43\" height=\"39\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Icons_lead-icon2.png\" alt=\"\" class=\"wp-image-1098\" style=\"width:20px\"\/><\/figure>\n\n\n\n<p style=\"border-style:none;border-width:0px;padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--20);padding-bottom:0;padding-left:var(--wp--preset--spacing--20)\">Lead<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-button\" style=\"border-style:none;border-width:0px\" data-selector=\"b528f1b7-7123-414d-884f-478054a3abb0\">\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"43\" height=\"39\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Icons_people-icon2.png\" alt=\"\" class=\"wp-image-1114\" style=\"width:20px\"\/><\/figure>\n\n\n\n<p style=\"border-style:none;border-width:0px;padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--20);padding-bottom:0;padding-left:var(--wp--preset--spacing--20)\">People<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-button\" style=\"border-style:none;border-width:0px\" data-selector=\"b528f1b7-7123-414d-884f-478054a3abb0\">\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"43\" height=\"39\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Icons_projects-icon2.png\" alt=\"\" class=\"wp-image-1120\" style=\"width:20px\"\/><\/figure>\n\n\n\n<p style=\"padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--20);padding-bottom:0;padding-left:var(--wp--preset--spacing--20)\">Projects<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-button\" style=\"border-style:none;border-width:0px\" data-selector=\"b528f1b7-7123-414d-884f-478054a3abb0\">\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"43\" height=\"39\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/09\/root_Icons_publications-icon2.png\" alt=\"\" class=\"wp-image-2818\" style=\"width:20px\"\/><\/figure>\n\n\n\n<p style=\"padding-top:var(--wp--preset--spacing--20);padding-right:var(--wp--preset--spacing--20);padding-bottom:0;padding-left:var(--wp--preset--spacing--20)\">Publications<\/p>\n<\/div>\n<\/div>\n<\/div><button class=\"etb-scroll-button left\" aria-label=\"Scroll to the left\"><span class=\"chevron-left\"><\/span><\/button><button class=\"etb-scroll-button right\" aria-label=\"Scroll to the right\"><span class=\"chevron-right\"><\/span><\/button><\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-contents has-border-color has-accent-6-border-color\" style=\"border-width:1px\">\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-slide-up\" data-selector=\"b528f1b7-7123-414d-884f-478054a3abb0\">    <div class=\"team-block-page\">\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"207\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/thumb_Blog_Gemma-Figtree-b_w550_h380_fcrop-300x207.webp\" class=\" wp-post-image\" alt=\"Professor Gemma Figtree\" srcset=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/thumb_Blog_Gemma-Figtree-b_w550_h380_fcrop-300x207.webp 300w, https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/thumb_Blog_Gemma-Figtree-b_w550_h380_fcrop.webp 550w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>                <div class=\"team-member-content\">\n                    <h3>Professor Gemma Figtree<\/h3>\n                    <div class=\"team-content\">\n                        \n<p class=\"is-style-text-subtitle\" style=\"font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.191), 0.98rem);\">Cardiovascular Discovery<br>Medicine, Northern Clinical School<br>Member of the Charles Perkins Centre<\/p>\n\n\n\n<p><\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-slide-up\" data-selector=\"b528f1b7-7123-414d-884f-478054a3abb0\">    <div class=\"team-block-page\">\n                    <div class=\"team-member\">\n                <img loading=\"lazy\" decoding=\"async\" width=\"181\" height=\"231\" src=\"https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/08\/Team_Dr-Owen-Tang-181x231-1.jpg\" class=\" wp-post-image\" alt=\"Dr Owen Tang\u00a0\" \/>                <div class=\"team-member-content\">\n                    <h3>Dr Owen Tang<\/h3>\n                    <div class=\"team-content\">\n                        \n<p class=\"is-style-text-subtitle\" style=\"font-size:clamp(0.875rem, 0.875rem + ((1vw - 0.2rem) * 0.191), 0.98rem);\">Research Fellow<br>Cardiovascular Discovery<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Michael Gray<\/h3>\n                    <div class=\"team-content\">\n                        <p>PhD Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Vicki Snelson<\/h3>\n                    <div class=\"team-content\">\n                        <p>Operations Manager<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Dr Zara Ali<\/h3>\n                    <div class=\"team-content\">\n                        <p>Research Program Manager<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Jessica Hu \u2013 Clinical Research Assistant<\/h3>\n                    <div class=\"team-content\">\n                                            <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Tung Nguyen \u2013 Clinical Trial Coordinator<\/h3>\n                    <div class=\"team-content\">\n                                            <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Suzanne Avis<\/h3>\n                    <div class=\"team-content\">\n                        <p>PhD Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Soloman Saleh<\/h3>\n                    <div class=\"team-content\">\n                        <p>PhD Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Cheryl Macadam \u2013 Clinical Trials Nurse<\/h3>\n                    <div class=\"team-content\">\n                                            <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Daniel Cheng \u2013 PhD student<\/h3>\n                    <div class=\"team-content\">\n                                            <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Cameron Evans<\/h3>\n                    <div class=\"team-content\">\n                        <p>PhD Student<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Patricia Schwarzkopf<\/h3>\n                    <div class=\"team-content\">\n                        <p>Research Assistant<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Madhuvanthi Chandrakanthan<\/h3>\n                    <div class=\"team-content\">\n                        <p>Postdoctoral Research Associate<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"team-member\">\n                                <div class=\"team-member-content\">\n                    <h3>Tena Carolina<\/h3>\n                    <div class=\"team-content\">\n                        <p>Research Admin Officer<\/p>\n                    <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-slide-up\" data-selector=\"b528f1b7-7123-414d-884f-478054a3abb0\">\n<h3 class=\"wp-block-heading\">The role of redox signalling in cardiovascular disease<\/h3>\n\n\n\n<p>Oxidative stress is a major driver of cellular dysfunction leading to cardiovascular disease.<\/p>\n\n\n\n<p>Our group strives to understand the way reactive oxygen species affect disease in the heart and blood vessels, by investigating molecular mechanisms and testing different therapies to prevent it.<\/p>\n\n\n\n<p>Current Projects:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Investigating the post transcriptional regulation of FXYD1 by microRNAs<\/li>\n\n\n\n<li>Investigating the role of FXYD1 in stable and unstable atherosclerosis<\/li>\n\n\n\n<li>Identifying new therapeutic targets in cardiac remodeling and fibrosis<\/li>\n\n\n\n<li>Investigating the protective role of FXYD1 in diabetic cardiac fibrosis<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">New targeted anti-inflammatory strategies in cardiovascular disease<\/h3>\n\n\n\n<p>Atherosclerosis develops when fatty deposits on arterial walls cause clogging, potentially causing conditions such as coronary artery disease or angina.<\/p>\n\n\n\n<p>Inflammation plays a role in atherosclerosis development and progression. However, our current understanding of the mechanisms involved is very limited.<\/p>\n\n\n\n<p>Our group focus on investigating the specific factors driving inflammation that lead to heart disease. This insight has the potential to identify markers to better predict the risk of patients and may also aid the development of novel therapeutic strategies.<\/p>\n\n\n\n<p>Current projects:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Investigating novel P2X7R antagonists in stable and unstable atherosclerosis<\/li>\n\n\n\n<li>Screening novel P2X7R antagonists for anti-inflammatory effects<\/li>\n\n\n\n<li>What is the therapeutic efficacy of the novel P2X7 antagonist in attenuating diabetes associated -atherosclerosis and diabetic cardiomyopathy?<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Discovery of novel and predictive biomarkers of cardiovascular disease<\/h3>\n\n\n\n<p>Despite common perception that cardiovascular disease is well understood and managed, it remains the leading killer of Australians. Major advances have been made in the identification and treatment of modifiable risk factors for cardiovascular disease in the community. However, at an individual case level, it is not uncommon for a patient to present with extensive atherosclerosis without adequate explanation.<\/p>\n\n\n\n<p>Current atherosclerotic biomarkers: Until recently, clinicians were limited to clinical history of modifiable risk factors, family history, and lipid profile to try to predict risk of atherosclerotic events. While all these factors reflect statistical risk, they fail to take into account individual phenotypes mediating the \u201chost response\u201d. The advent of CT coronary angiography and calcium scoring is a major step forward in terms of identifying early disease. However, they are not considered suitable for mass community screening. The ideal tool that we are currently missing is a blood biomarker reflecting early phase atherosclerotic disease activity. Such a biomarker should integrate not only the risk of plaque development, but also the \u201chost response\u201d at the level of the arterial wall. This combination of risk and host response should improve the precision of preventative therapies relevant to the individual.<\/p>\n\n\n\n<p>Current Projects:<\/p>\n\n\n\n<p>BioHEART is a platform for discovery of new mechanisms of both vulnerability, as well as resilience to atherosclerosis. A prospective study would involve patients undergoing CT coronary angiogram across the Sydney Health Partners network.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-easy-tabs-block-tab-content etb-animation-slide-up\" data-selector=\"b528f1b7-7123-414d-884f-478054a3abb0\">\n<p><a rel=\"noreferrer noopener\" href=\"http:\/\/sydney.edu.au\/medicine\/people\/academics\/profiles\/gemma.figtree.php#publications-by-year\" target=\"_blank\">http:\/\/sydney.edu.au\/medicine\/people\/academics\/profiles\/gemma.figtree.php#publications-by-year<\/a><\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"http:\/\/sydney.edu.au\/medicine\/people\/academics\/profiles\/belinda.dibartolo.php#publications-by-year\" target=\"_blank\">http:\/\/sydney.edu.au\/medicine\/people\/academics\/profiles\/belinda.dibartolo.php#publications-by-year<\/a><\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n","protected":false},"featured_media":381,"template":"","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","footnotes":""},"research-group-tax":[],"primary-research-area":[58],"class_list":["post-2656","research-group","type-research-group","status-publish","has-post-thumbnail","hentry","primary-research-area-cardiovascular-and-renal"],"acf":{"team_leads":[3192],"team_members":[3193,3437,3438,3439,3440,3441,3444,3445,3447,3449,3451,3452,3455,3456,3458]},"uagb_featured_image_src":{"full":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_All-research-teams-banner.jpg",1920,815,false],"thumbnail":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_All-research-teams-banner-150x150.jpg",150,150,true],"medium":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_All-research-teams-banner-300x127.jpg",300,127,true],"medium_large":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_All-research-teams-banner-768x326.jpg",768,326,true],"large":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_All-research-teams-banner-1024x435.jpg",1024,435,true],"1536x1536":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_All-research-teams-banner-1536x652.jpg",1536,652,true],"2048x2048":["https:\/\/kollinginstitute.org.au\/news_demo\/wp-content\/uploads\/2025\/07\/root_Banners_All-research-teams-banner.jpg",1920,815,false]},"uagb_author_info":{"display_name":"ict-wordpress-support@sydney.edu.au","author_link":"https:\/\/kollinginstitute.org.au\/news_demo\/author\/"},"uagb_comment_info":0,"uagb_excerpt":"The Cardiovascular Discovery Group focuses on identifying new ways to treat cardiovascular disease. The key aim of our research is to improve the survival and wellbeing of people with heart disease and those who are susceptible to developing the disease. We do this through a research program of translational and clinical research. 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